Grant number: 209057
NP Tjader, J Ramroop, T Gandhi, C Dauch, O Meadows, P Stevens, R Pearlman, H Hampel, EK Aglago, SI Berndt, A Bloomer, H Brenner, DD Buchanan, PT Campbell, Y Cao, AT Chan, I Cheng, N Dimou, DA Drew, AJ French
2026-12-01
Somatic mutations in KRAS are a common driver of colorectal cancer (CRC) and present at different frequencies by race, sex, tumor ..
TA Harrison, SH Zaidi, H Yin, RS Steinfelder, C Qu, EK Aglago, SI Berndt, LA Boardman, H Brenner, DD Buchanan, PT Campbell, Y Cao, AT Chan, SJ Chanock, KF Doheny, DA Drew, JC Figueiredo, AJ French, S Gallinger, P Georgeson
Background: Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in t..
AA Mathew, Y Peng, JK Bassett, AM Hodge, N Afshar, RJ MacInnis, BM Lynch, SA Smith-Warner, MM Shams-White, GG Giles, RL Milne, H Jayasekara
2026-08-01
Background: We investigated the associations between adherence to the 2018 World Cancer Research Fund/American Institute for Cance..
CV Chalitsios, WC Chan, G Markozannes, EK Aglago, SI Berndt, DD Buchanan, PT Campbell, Y Cao, N Dimou, DA Drew, AJ French, S Gallinger, P Georgeson, M Giannakis, SB Gruber, MJ Gunter, TA Harrison, H Brenner, M Hoffmeister, MJ Urruchúa-Rodríguez
2026-06-01
Background: Alcohol consumption is associated with colorectal cancer (CRC) risk, yet its association with distinct molecular subty..
Austin Hammermeister Suger, Hongjie Chen, Cameron B Haas, Shaoqi Fan, Christopher G Scott, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Kyriaki Michailidou, Qin Wang, Peter A Fasching, Lothar Haeberle, Jennifer Stone, Manuela Gago-Dominguez, Jose E Castelao, Rachel A Murphy, Kristan Aronson, Fergus J Couch, Siddhartha Yadav, Roger L Milne
2026-05-07
Studies have identified genetic and epidemiologic factors associated with mammographic density (MD) phenotypes. However, MD-associ..
DL Li, J Ryan, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué
2026-05-01
Epigenetic alterations are an important shared hallmark of ageing and cancer. The development of epigenetic markers of ageing usin..
Z Ye, R Xu, GL Malone, PA Dugué, TL Nguyen, GG Giles, MC Southey, RL Milne, S Li
2026-04-01
Abstract STUDY QUESTION Do genome-wide DNA methylation patterns influence age at menarche? SUMMARY ANSWER An epigenome-wide associ..
Habtamu B Beyene, Tingting Wang, Michelle Cinel, Natalie A Mellett, Thy Duong, Matilda van Buuren-Milne, Alexandra N Faulkner, Jingqin Wu, Gavriel Olshansky, Jonathan E Shaw, Dianna J Magliano, Melissa C Southy, Roger L Milne, Allison M Hodge, Corey Giles, Kevin Huynh, Peter J Meikle
2026-03-30
Diet is a key factor for many diseases, yet the underlying metabolic pathways involved remain poorly understood. We analyze data f..
T Zhang, X Hua, C Mohindroo, X Wang, D Dutta, J Liu, S Katta, SA Li, J Wang, SO Antwi, AA Arslan, LE Beane Freeman, PM Bracci, F Canzian, M Du, S Gallinger, PJ Goodman, V Katzke, C Kooperberg, L Le Marchand
2026-03-01
Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architectur..
JL Vassy, AM Dornisch, R Karunamuni, M Gatzen, CJ Kachulis, NJ Lennon, CA Brunette, ME Danowski, RL Hauger, IP Garraway, AS Kibel, KM Lee, JA Lynch, KN Maxwell, D Ratner, BS Rose, CC Teerlink, GJ Xu, SE Hofherr, KA Lafferty
2026-02-01
Precision healthcare aims to tailor disease prevention and early detection to individual risk. Prostate cancer screening may benef..
HM Tanha, MH Law, N Ingold, CM Olsen, N Pandeya, RL Milne, RJ MacInnis, DC Whiteman, AE Cust, J Steinberg
Polygenic risk scores (PGS) have the potential to support enhanced, risk-based screening for breast cancer. Previous studies for m..
DL Li, AM Hodge, J Ryan, MC Southey, GG Giles, RL Milne, PA Dugué
2026-01-01
Several methylation-based surrogate markers of C-reactive protein (mCRP) have been proposed and used to assess the risk of age-rel..
A Moore, E Kane, LR Teras, MJ Machiela, J Arias, OA Panagiotou, A Monnereau, NW Doo, Z Wang, SL Slager, RCH Vermeulen, CM Vajdic, KE Smedby, JJ Spinelli, J Vijai, GG Giles, BK Link, AA Arslan, A Nieters, PM Bracci
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between..
Ricardo Cortez Cardoso Penha, Justina Ucheojor Onwuka, Ryan Langdon, Torkjel M Sandanger, Therese Haugdahl Nøst, Paolo Vineis, Mikael Johansson, Roger L Milne, Pierre-Antoine Dugué, Caroline Relton, Matthew Suderman, James McKay, Mattias Johansson
2025-12-17
BACKGROUND: Biological age, estimated by DNA methylation-based (DNAm) clocks, has been reported to be associated with lung cancer ..
E Ebrahimi, S Naudin, N Dimou, AL Mayén, M Wang, CC Abnet, A Åkesson, MJ Barnett, R Bellocco, A Berrington De Gonzalez, SE Bonn, C Chen, DC Christiani, TE Crane, AH Eliassen, JL Freudenheim, YT Gao, M Garcia-Closas, G Gierach, EL Giovannucci
2025-12-01
Background This study aimed to investigate the association between alcohol consumption and squamous cell cancers of the upper aero..
M Zanti, DG O’Mahony, MT Parsons, L Dorling, J Dennis, NJ Boddicker, W Chen, C Hu, M Naven, K Yiangou, TU Ahearn, CB Ambrosone, IL Andrulis, AC Antoniou, PL Auer, C Baynes, C Bodelon, NV Bogdanova, SE Bojesen, MK Bolla
Clinical genetic testing identifies variants causal for hereditary cancer, information that is used for risk assessment and clinic..
KD Brantley, ME Jones, RM Tamimi, BA Rosner, P Kraft, HB Nichols, KM O’Brien, HO Adami, A Aizpurua, AB de Gonzalez, WJ Blot, T Braaten, Y Chen, JC DeHart, L Dossus, S Elias, RT Fortner, M Garcia-Closas, IT Gram, N Håkansson
Background: Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are..
DR Barnes, JP Tyrer, J Dennis, G Leslie, MK Bolla, M Lush, AM Aeilts, K Aittomäki, N Andrieu, IL Andrulis, H Anton-Culver, A Arason, BK Arun, J Balmaña, EV Bandera, RB Barkardottir, LPV Berger, A Berrington de Gonzalez, P Berthet, K Białkowska
Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants..
DL Li, X Xu, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué
Objectives Social relationships play an important role in maintaining physical and psychological health. Epigenetic age is a poten..
E Zarean, S Li, EM Wong, E Makalic, RL Milne, GG Giles, C McLean, MC Southey, PA Dugué
Background: Tumour DNA methylation has been investigated as a potential marker for breast cancer survival, but findings often lack..
H Jayasekara, JK Bassett, HHF Tang, Y Peng, H Tsimiklis, RL O'Reilly, BM Lynch, RJ MacInnis, GG Giles, MC Southey, RL Milne, MC Camargo
2025-11-01
Background: Autoimmune gastritis poses a risk for stomach cancer. However, its role relative to Helicobacter pylori-associated gas..
Sarah Gauci, Mojtaba Lotfaliany, Priscila Machado, Allison Hodge, Elizabeth Gamage, Renata Bertazzi Levy, Maria Laura da Costa Louzada, Julie Redfern, Adrienne O'Neil, Wolfgang Marx, Melissa M Lane
Aims There has been a global shift from nutrient-dense diets to an ultra-processed food pattern, which is linked to adverse health..
Robel Hussen Kabthymer, Tongzhi Wu, Sara Beigrezaei, Oscar H Franco, Allison M Hodge, Barbora de Courten
AIM: Globally, sugar intake from sugar-sweetened beverages (SSBs) exceeds the daily recommended limits for intake levels of free s..
E Bouras, R Yu, AE Kim, G Markozannes, N Murphy, D Albanes, LN Anderson, EL Barry, SI Berndt, DT Bishop, H Brenner, A Burnett-Hartman, PT Campbell, R Carreras-Torres, AT Chan, I Cheng, MA Devall, V Diez-Obrero, N Dimou, DA Drew
Background: Colorectal cancer (CRC) is a significant public health concern, highlighting the critical need for identifying novel i..
HM Tanha, MH Law, N Ingold, P Ly, CM Olsen, N Pandeya, DP Smith, RJ MacInnis, DC Whiteman, AE Cust, J Steinberg
2025-10-09
Risk-based approaches offer promise for enhancing early detection of prostate cancer. Polygenic risk scores (PGSs) have emerged as..
2025-10-01
Background: Psychological distress is associated with adverse health outcomes. We aimed to assess whether the health impacts of ps..
N Davoodian, M Lotfaliany, RR Huxley, CMY Lee, JA Pasco, RJ Adams, F Azizi, AG Bertoni, C Björkelund, S Colagiuri, N Fahimfar, R Gabriel, V Giedraitis, TK Gill, C González, EW Gregg, F Hadaegh, D Hange, JW Harland, AM Hodge
2025-09-01
Background: With the increasing global burden of type 2 diabetes, prevention strategies that target prediabetes, a state of hyperg..
D Ramachandran, X Wang, T Laisk, Y Zheng, N Ingold, DM Canson, PF Kho, BJ Naumann, CJ Chapman, K Bousset, AV Krause, P Schürmann, B Wieland, P Hanel, F Hülse, N Häfner, I Runnebaum, N Dubrowinskaja, N Turmanov, T Yugay
2025-08-01
Background: Endometrial cancer is the most common gynaecological cancer in high-income countries. In addition to environmental ris..
DL Li, AM Hodge, MC Southey, GG Giles, PA Dugué
2025-07-01
Background: Type 2 diabetes (T2D) is characterized by elevated levels of metabolic and inflammatory markers but less is known abou..
JK Bassett, Y Peng, RJ MacInnis, AM Hodge, BM Lynch, R Room, GG Giles, RL Milne, H Jayasekara
2025-04-01
Background: Published studies rarely assess associations between trajectories of drinking and mortality. Methods: We aimed to asse..
L Cribb, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué
The role of nutrition in healthy ageing is acknowledged but details of optimal dietary composition are still uncertain. We aimed t..
FEM Albers, CTV Swain, MWC Lou, SG Dashti, S Rinaldi, V Viallon, A Karahalios, KA Brown, MJ Gunter, RL Milne, DR English, BM Lynch
Background: Higher concentration of insulin-like growth factor-1 (IGF-1) increases postmenopausal breast cancer risk, but evidence..
YL Chu, P Georgeson, M Clendenning, K Mahmood, R Walker, J Como, S Joseland, SG Preston, T Rice, BM Lynch, RL Milne, MC Southey, GG Giles, AI Phipps, JL Hopper, AK Win, C Rosty, FA Macrae, I Winship, MA Jenkins
Background: The adverse gut microbiome may underlie the variability in risks of colorectal cancer (CRC) and metachronous CRC in pe..
HT Zheng, DL Li, MWC Lou, AM Hodge, MC Southey, GG Giles, RL Milne, BM Lynch, PA Dugué
Epigenetic age quantifies biological age using DNA methylation information and is a potential pathway by which physical activity b..
CV Chalitsios, G Markozannes, C Papagiannopoulos, EK Aglago, SI Berndt, DD Buchanan, PT Campbell, Y Cao, AT Chan, N Dimou, DA Drew, AJ French, P Georgeson, M Giannakis, SB Gruber, MJ Gunter, TA Harrison, M Hoffmeister, L Hsu, WY Huang
Background: Waist circumference (WC) and its allometric counterpart, “a body shape index” (ABSI), are risk factors for colorectal ..
S Naudin, M Wang, N Dimou, E Ebrahimi, J Genkinger, HO Adami, D Albanes, A Babic, M Barnett, D Bogumil, H Cai, C Chen, AH Eliassen, JL Freudenheim, G Gierach, EL Giovannucci, MJ Gunter, N Håkansson, M Hirabayashi, T Hou
2025-01-01
Background Alcohol is a known carcinogen, yet the evidence for an association with pancreatic cancer risk is considered as limited..
NM Viart, AL Renault, S Eon-Marchais, Y Jiao, L Fuhrmann, SM El Houdigui, D Le Gal, E Cavaciuti, MG Dondon, J Beauvallet, V Raynal, D Stoppa-Lyonnet, A Vincent-Salomon, N Andrieu, MC Southey, F Lesueur
Background: The ataxia-telangiectasia mutated (ATM) kinase phosphorylates and activates several downstream targets that are essent..
MJ Schoemaker, T Ellington, HB Nichols, LB Wright, ME Jones, KM O’Brien, CR Weinberg, HO Adami, L Baglietto, KA Bertrand, Y Chen, J Clague DeHart, AH Eliassen, GG Giles, SC Houghton, VA Kirsh, RL Milne, JR Palmer, HL Park, TE Rohan
Background: Among premenopausal women, higher body mass index (BMI) is associated with lower breast cancer risk, although the unde..
CE Thomas, Y Lin, M Kim, ES Kawaguchi, C Qu, CY Um, BM Lynch, B Van Guelpen, K Tsilidis, R Carreras-Torres, FJB Van Duijnhoven, LC Sakoda, PT Campbell, Y Tian, J Chang-Claude, S Bézieau, A Budiarto, JR Palmer, PA Newcomb, G Casey
Background: Colorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of ..
E Sidahmed, SJ Freedland, M Wang, K Wu, D Albanes, M Barnett, PA van den Brandt, MB Cook, GG Giles, E Giovannucci, CA Haiman, SC Larsson, TJ Key, E Loftfield, S Männistö, ML McCullough, RL Milne, ML Neuhouser, EA Platz, A Perez-Cornago
Background: Evidence of an association between dietary fiber intake and risk of advanced and aggressive forms of prostate cancer (..
S Li, GS Dite, RJ MacInnis, M Bui, TL Nguyen, VFC Esser, Z Ye, JG Dowty, E Makalic, J Sung, GG Giles, MC Southey, JL Hopper
2024-12-01
A polygenic risk score (PRS) combines the associations of multiple genetic variants that could be due to direct causal effects, in..
J O’Driscoll, A Burton, G Maskarinec, B Perez-Gomez, C Vachon, H Miao, M Lajous, R López-Ridaura, AH Eliassen, A Pereira, ML Garmendia, RM Tamimi, K Bertrand, A Kwong, G Ursin, E Lee, SA Qureshi, H Ma, S Vinnicombe, S Moss
Background: Elevated mammographic density (MD) for a woman’s age and body mass index (BMI) is an established breast cancer risk fa..
DL Li, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidence found ..
Jacob K Kresovich, Catherine Guranich, Serena Houghton, Jing Qian, Micheal E Jones, Maegan E Boutot, Mitch Dowsett, A Heather Eliassen, Montserrat Garcia-Closas, Peter Kraft, Aaron Norman, Michael Pollak, Sabina Rinaldi, Bernard Rosner, Minouk J Schoemaker, Christopher Scott, Anthony J Swerdlow, Roger L Milne, Shelley S Tworoger, Celine M Vachon
2024-11-26
BACKGROUND: Prolactin, a hormone produced by the pituitary gland, regulates breast development and may contribute to breast cancer..
BPM Kwan, BM Lynch, L Edbrooke, A Hodge, CTV Swain
2024-11-01
Background: Physical activity and sedentary behavior are associated with health outcomes. However, evidence may be affected by con..
CM Nagle, TI Ibiebele, EV Bandera, D Cramer, JA Doherty, GG Giles, MT Goodman, GE Hanley, HR Harris, A Jensen, SK Kjaer, AW Lee, RL Milne, B Qin, J Richardson, N Sasamoto, W Sieh, KL Terry, L Titus, B Trabert
2024-10-05
Background: Tea and coffee are the most frequently consumed beverages in the world. Green tea in particular contains compounds wit..
DM Gianferante, A Moore, LG Spector, W Wheeler, T Yang, A Hubbard, R Gorlick, A Patiño-Garcia, F Lecanda, AM Flanagan, F Amary, IL Andrulis, JS Wunder, DM Thomas, ML Ballinger, M Serra, C Hattinger, E Demerath, W Johnson, BM Birmann
2024-10-01
Introduction: Several studies have linked increased risk of osteosarcoma with tall stature, high birthweight, and early puberty, a..
Z Ni, P Kundu, DF McKean, W Wheeler, D Albanes, G Andreotti, SO Antwi, AA Arslan, WR Bamlet, LE Beane-Freeman, SI Berndt, PM Bracci, P Brennan, JE Buring, SJ Chanock, S Gallinger, JM Gaziano, GG Giles, EL Giovannucci, MG Goggins
2024-09-01
Background: Pancreatic cancer is a leading cause of cancer-related death globally. Risk factors for pancreatic cancer include comm..
Liesel M FitzGerald, Chol-Hee Jung, Ee Ming Wong, JiHoon E Joo, Julie K Bassett, James G Dowty, Xiaoyu Wang, James Y Dai, Janet L Stanford, Neil O'Callaghan, Tim Nottle, John Pedersen, Graham G Giles, Melissa C Southey
2024-08-02
Differentially methylated CpG sites (dmCpGs) that distinguish prostate tumour from adjacent benign tissue could aid in the diagnos..
Robel Hussen Kabthymer, Md Nazmul Karim, Catherine Itsiopoulos, Allison M Hodge, Barbora De Courten
2024-06-01
AIMS: We aimed to assess the association of a low carbohydrate diet score (LCD) with the incidence of type 2 diabetes (T2D) using ..
N Papadimitriou, A Kim, ES Kawaguchi, J Morrison, V Diez-Obrero, D Albanes, SI Berndt, S Bézieau, SA Bien, DT Bishop, E Bouras, H Brenner, DD Buchanan, PT Campbell, R Carreras-Torres, AT Chan, J Chang-Claude, DV Conti, MA Devall, N Dimou
Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide ge..
Frances EM Albers, Makayla WC Lou, S Ghazaleh Dashti, Christopher TV Swain, Sabina Rinaldi, Vivian Viallon, Amalia Karahalios, Kristy A Brown, Marc J Gunter, Roger L Milne, Dallas R English, Brigid M Lynch
Purpose: Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pat..
DL Li, AM Hodge, L Cribb, MC Southey, GG Giles, RL Milne, PA Dugué
2024-04-01
Epigenetic age is an emerging marker of health that is highly predictive of disease and mortality risk. There is a lack of evidenc..
CE Thomas, P Georgeson, C Qu, RS Steinfelder, DD Buchanan, M Song, TA Harrison, CY Um, MA Hullar, MA Jenkins, B Van Guelpen, BM Lynch, YA Melaku, JR Huyghe, EK Aglago, SI Berndt, LA Boardman, PT Campbell, Y Cao, AT Chan
Background: The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whet..
Nikos Papadimitriou, Conghui Qu, Tabitha A Harrison, Alaina M Bever, Richard M Martin, Konstantino K Tsilidis, Polly A Newcomb, Stephen N Thibadeau, Christina C Newton, Caroline Y Um, Mireia Obon-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J Pellatt, Robert E Schoen, Sophia Harlid, Shuji Ogino
2024-03-01
Background: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude..
J Yarmolinsky, JW Robinson, D Mariosa, V Karhunen, J Huang, N Dimou, N Murphy, K Burrows, E Bouras, K Smith-Byrne, SJ Lewis, TE Galesloot, LA Kiemeney, S Vermeulen, P Martin, D Albanes, L Hou, PA Newcomb, E White, A Wolk
2024-02-01
Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links b..
TJ O’Grady, S Rinaldi, KA Michels, HO Adami, JE Buring, Y Chen, TV Clendenen, A D’Aloisio, JC DeHart, S Franceschi, ND Freedman, GL Gierach, GG Giles, JV Lacey, IM Lee, LM Liao, MS Linet, ML McCullough, AV Patel, A Prizment
Background: The incidence of differentiated thyroid cancer (DTC) is higher in women than in men but whether sex steroid hormones c..
Y Peng, JK Bassett, AM Hodge, YA Melaku, N Afshar, JL Hopper, RJ MacInnis, BM Lynch, SA Smith-Warner, GG Giles, RL Milne, H Jayasekara
2024-01-10
Background: We examined associations between adherence to adaptations of the 2018World Cancer Research Fund/American Institute for..
Evertine Wesselink, William Gauderman, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Michelle Cotterchoi, Marc J Gunter, Michael Hoffmeister, Amit D Joshi, Christina C Newton, Rish K Pai, Andrew J Pellatt, Amanda I Phipps, Mingyang Song, Caroline Y Um, Bethany van Guelpen, Emily White
2024-01-01
BACKGROUND: Research on calcium intake as well as variants in the calcium sensor receptor (CaSR) gene and their interaction in rel..
Yu Tian, Yi Lin, Conghui Qu, Volker Arndt, James W Baurley, Sonja I Berndt, Stephanie A Bien, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Arif Budiarto, Peter T Campbell, Robert Carreras-Torres, Graham Casey, Andrew T Chan, Rui Chen, Xuechen Chen, David V Conti, Virginia Diez-Obrero, Niki Dimou
Background: Menopausal hormone therapy (MHT), a common treatment to relieve symptoms of menopause, is associated with a lower risk..
Ø Midttun, A Ulvik, K Meyer, H Zahed, GG Giles, J Manjer, M Sandsveden, A Langhammer, EP Sørgjerd, AF Behndig, M Johansson, ND Freedman, WY Huang, C Chen, R Prentice, VL Stevens, Y Wang, L Le Marchand, SJ Weinstein, Q Cai
2023-12-01
Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism inc..
H Levi, S Carmi, S Rosset, R Yerushalmi, A Zick, T Yablonski-Peretz, Q Wang, MK Bolla, J Dennis, K Michailidou, M Lush, T Ahearn, IL Andrulis, H Anton-Culver, AC Antoniou, V Arndt, A Augustinsson, P Auvinen, LB Freeman, M Beckmann
Background Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC)..
D Albanes, K Alcala, N Alcala, CI Amos, AA Arslan, JK Bassett, P Brennan, Q Cai, C Chen, X Feng, ND Freedman, F Guida, RJ Hung, K Hveem, M Johansson, M Johansson, WP Koh, A Langhammer, RL Milne, D Muller
Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 pr..
D Mizrahi, CTV Swain, F Bruinsma, A Hodge, N Taylor, BM Lynch
2023-10-01
Background: There is increasing evidence for the relationship between physical activity (PA), sedentary behaviour and mental healt..
Maria Zanti, Denise G O'Mahony, Michael T Parsons, Hongyan Li, Joe Dennis, Kristiina Aittomakkiki, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Melissa A Brown, Saundra S Buys, Federico Canzian, Sandrine M Caputo, Jose E Castelao, Jenny Chang-Claude
2023-09-14
A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significan..
Kristina Vingrys, Michael L Mathai, Andrew J McAinch, Julie K Bassett, Maximilian de Courten, Lily Stojanovska, Lynne Millar, Graham G Giles, Allison M Hodge, Vasso Apostolopoulos
2023-09-13
Background: Cereal-derived polyphenols have demonstrated protective mechanisms in colorectal cancer (CRC) models; however, confirm..
X Feng, WYY Wu, JU Onwuka, Z Haider, K Alcala, K Smith-Byrne, H Zahed, F Guida, R Wang, JK Bassett, V Stevens, Y Wang, S Weinstein, ND Freedman, C Chen, L Tinker, TH Nøst, WP Koh, D Muller, SM Colorado-Yohar
2023-09-01
Background: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in..
N Dimou, AE Kim, O Flanagan, N Murphy, V Diez-Obrero, A Shcherbina, EK Aglago, E Bouras, PT Campbell, G Casey, S Gallinger, SB Gruber, MA Jenkins, Y Lin, V Moreno, E Ruiz-Narvaez, MC Stern, Y Tian, KK Tsilidis, V Arndt
2023-08-24
Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship sti..
MM Lane, M Lotfaliany, AM Hodge, A O'Neil, N Travica, FN Jacka, T Rocks, P Machado, M Forbes, DN Ashtree, W Marx
2023-08-15
Background: Few studies have tested longitudinal associations between ultra-processed food consumption and depressive outcomes. As..
EK Aglago, A Kim, Y Lin, C Qu, M Evangelou, Y Ren, J Morrison, D Albanes, V Arndt, EL Barry, JW Baurley, SI Berndt, SA Bien, DT Bishop, E Bouras, H Brenner, DD Buchanan, A Budiarto, R Carreras-Torres, G Casey
2023-08-01
Colorectal cancer risk can be impacted by genetic, environ-SNP was also identified by the 3DF test, with a suggestive statimental,..
PA Dugué, C Yu, AM Hodge, EM Wong, JHE Joo, CH Jung, D Schmidt, E Makalic, DD Buchanan, G Severi, DR English, JL Hopper, RL Milne, GG Giles, MC Southey
Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better capture current and..
ZJ Phua, RJ MacInnis, AM Hodge, BM Lynch, JL Hopper, SA Smith-Warner, GG Giles, RL Milne, H Jayasekara
Enhanced survival following a diagnosis of cancer has led to a steep rise in the number of individuals diagnosed with a second pri..
S Koutros, LA Kiemeney, P Pal Choudhury, RL Milne, E Lopez de Maturana, Y Ye, V Joseph, O Florez-Vargas, L Dyrskjøt, J Figueroa, D Dutta, GG Giles, MAT Hildebrandt, K Offit, M Kogevinas, E Weiderpass, ML McCullough, ND Freedman, D Albanes, C Kooperberg
2023-07-01
Background: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into..
JG Dowty, C Yu, M Hosseinpour, JE Joo, EM Wong, T Nguyen-Dumont, J Rosenbluh, GG Giles, RL Milne, RJ MacInnis, PA Dugué, MC Southey
DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part ..
Robel Hussen Kabthymer, Md Nazmul Karim, Allison M Hodge, Barbora de Courten
AIM: To assess the associations of total dietary fibre and fibre from different food sources (ie, cereal, fruit and vegetables) wi..
G Figlioli, A Billaud, Q Wang, MK Bolla, J Dennis, M Lush, A Kvist, MA Adank, TU Ahearn, NN Antonenkova, P Auvinen, S Behrens, M Bermisheva, NV Bogdanova, SE Bojesen, B Bonanni, T Brüning, NJ Camp, A Campbell, JE Castelao
FANCM germline protein truncating variants (PTVs) are moderate-risk factors for ER-negative breast cancer. We previously described..
X Feng, DC Muller, H Zahed, K Alcala, F Guida, K Smith-Byrne, JM Yuan, WP Koh, R Wang, RL Milne, JK Bassett, A Langhammer, K Hveem, VL Stevens, Y Wang, M Johansson, A Tjønneland, R Tumino, M Sheikh, M Johansson
2023-06-01
Background: To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they ca..
HB Nichols, MG House, R Yarosh, S Mitra, M Goldberg, KA Bertrand, AH Eliassen, GG Giles, ME Jones, RL Milne, KM O’Brien, JR Palmer, S Sandin, WC Willett, W Yin, DP Sandler, AJ Swerdlow, MJ Schoemaker
Purpose: Women with preeclampsia are more likely to deliver preterm. Reports of inverse associations between preeclampsia and brea..
Kristina Vingrys, Michael L Mathai, Vasso Apostolopoulos, Julie K Bassett, Maximilian de Courten, Lily Stojanovska, Lynne Millar, Graham G Giles, Roger L Milne, Allison M Hodge, Andrew J McAinch
2023-05-26
Cereal foods are consumed globally and are important sources of polyphenols with potential health benefits, yet dietary intakes ar..
James Yarmolinsky, Jamie W Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J Lewis, Tessel E Galesloot, Lambertus A Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A Newcomb, Emily White, Alicja Wolk
2023-05-05
BACKGROUND: Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links b..
ME Wang, AM Hodge, SX Li, MC Southey, GG Giles, PA Dugué
2023-05-01
Aim: The kynurenine pathway is increasingly recognised to play a role in inflammation and disease. We assessed the cross-sectional..
SE Wang, A Hodge, SG Dashti, SC Dixon-Suen, N Castaño-Rodríguez, R Thomas, G Giles, A Boussioutas, B Kendall, DR English
2023-04-14
Barrett's oesophagus (BE) is the precursor of oesophageal adenocarcinoma, which has become the most common type of oesophageal can..
MA Laaksonen, S Li, K Canfell, RJ MacInnis, GG Giles, E Banks, JE Byles, DJ Magliano, JE Shaw, TK Gill, V Hirani, RG Cumming, P Mitchell, M Bonello, BA Adelstein, AW Taylor, K Price, CM Vajdic
2023-04-06
Background: We quantified the individual and joint contribution of contemporaneous causal behavioural exposures on the future burd..
T Ugai, N Akimoto, K Haruki, TA Harrison, Y Cao, C Qu, AT Chan, PT Campbell, SI Berndt, DD Buchanan, AJ Cross, B Diergaarde, SJ Gallinger, MJ Gunter, S Harlid, A Hidaka, M Hoffmeister, H Brenner, J Chang-Claude, L Hsu
2023-03-01
Background: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those rel..
SM Hussain, IN Ackerman, Y Wang, DR English, AE Wluka, GG Giles, FM Cicuttini
Objective: To examine the association between body mass index (BMI) trajectories from early adulthood to late midlife and risk of ..
N Murphy, CC Newton, M Song, N Papadimitriou, M Hoffmeister, AI Phipps, TA Harrison, PA Newcomb, EK Aglago, SI Berndt, H Brenner, DD Buchanan, Y Cao, AT Chan, X Chen, I Cheng, J Chang-Claude, N Dimou, D Drew, AB Farris
2023-02-01
Background: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsisten..
N Afshar, AM Hodge, N Shivappa, JR Hébert, GG Giles, DR English, RL Milne
Background: Previous studies of dietary patterns and pancreatic cancer risk have been inconclusive; we aimed to investigate the as..
Gisella Figlioli, Amandine Billaud, Thomas U Ahearn, Natalia N Antonenkova, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Marinus J Blok, Natalia V Bogdanova, Bernardo Bonanni, Barbara Burwinkel, Nicola J Camp, Archie Campbell, Jose E Castelao, Melissa H Cessna, Stephen J Chanock, Kamila Czene, Peter Devilee
2023-01-01
Evidence from literature, including the BRIDGES study, indicates that germline protein truncating variants (PTVs) in FANCM confer ..
AY Jung, TU Ahearn, S Behrens, P Middha, MK Bolla, Q Wang, V Arndt, KJ Aronson, A Augustinsson, LE Beane Freeman, H Becher, H Brenner, F Canzian, LA Carey, K Czene, AH Eliassen, M Eriksson, DG Evans, JD Figueroa, L Fritschi
2022-12-01
Background: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER)-positive and ..
JD Labadie, S Savas, TA Harrison, B Banbury, Y Huang, DD Buchanan, PT Campbell, SJ Gallinger, GG Giles, MJ Gunter, M Hoffmeister, L Hsu, MA Jenkins, Y Lin, S Ogino, AI Phipps, ML Slattery, RS Steinfelder, W Sun, B Van Guelpen
Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine geno..
X Wang, PM Kapoor, PL Auer, J Dennis, AM Dunning, Q Wang, M Lush, K Michailidou, MK Bolla, KJ Aronson, RA Murphy, A Brooks-Wilson, DG Lee, E Cordina-Duverger, P Guénel, T Truong, C Mulot, LR Teras, AV Patel, L Dossus
Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and ..
L Cribb, AM Hodge, C Yu, SX Li, DR English, E Makalic, MC Southey, RL Milne, GG Giles, PA Dugu
Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and pros..
CB Haas, YR Su, P Petersen, X Wang, SA Bien, Y Lin, D Albanes, SJ Weinstein, MA Jenkins, JC Figueiredo, PA Newcomb, G Casey, L Le Marchand, PT Campbell, V Moreno, JD Potter, LC Sakoda, ML Slattery, AT Chan, L Li
Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understand..
J Dennis, JP Tyrer, LC Walker, K Michailidou, L Dorling, MK Bolla, Q Wang, TU Ahearn, IL Andrulis, H Anton-Culver, NN Antonenkova, V Arndt, KJ Aronson, LEB Freeman, MW Beckmann, S Behrens, J Benitez, M Bermisheva, NV Bogdanova, SE Bojesen
Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not ..
CTV Swain, JK Bassett, AM Hodge, DW Dunstan, N Owen, Y Yang, H Jayasekara, JR Hébert, N Shivappa, RJ MacInnis, RL Milne, DR English, BM Lynch
Background: Higher levels of time spent sitting (sedentary behavior) contribute to adverse health outcomes, including earlier deat..
SV Ward, A Burton, RM Tamimi, A Pereira, ML Garmendia, M Pollan, N Boyd, I dos-Santos-Silva, G Maskarinec, B Perez-Gomez, C Vachon, H Miao, M Lajous, R López-Ridaura, K Bertrand, A Kwong, G Ursin, E Lee, H Ma, S Vinnicombe
Background: Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these ass..
AA Devries, J Dennis, JP Tyrer, PC Peng, SG Coetzee, AL Reyes, JT Plummer, BD Davis, SS Chen, FS Dezem, KKH Aben, H Anton-Culver, NN Antonenkova, MW Beckmann, A Beeghly-Fadiel, A Berchuck, NV Bogdanova, N Bogdanova-Markov, JD Brenton, R Butzow
2022-11-01
Background: Known risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy..
L Yengo, S Vedantam, E Marouli, J Sidorenko, E Bartell, S Sakaue, M Graff, AU Eliasen, Y Jiang, S Raghavan, J Miao, JD Arias, SE Graham, RE Mukamel, CN Spracklen, X Yin, SH Chen, T Ferreira, HH Highland, Y Ji
2022-10-27
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height..
SC Dixon-Suen, SJ Lewis, RM Martin, DR English, T Boyle, GG Giles, K Michailidou, MK Bolla, Q Wang, J Dennis, M Lush, A Investigators, TU Ahearn, CB Ambrosone, IL Andrulis, H Anton-Culver, V Arndt, KJ Aronson, A Augustinsson, P Auvinen
2022-09-06
Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but..
I Grootes, R Keeman, FM Blows, RL Milne, GG Giles, AJ Swerdlow, PA Fasching, M Abubakar, IL Andrulis, H Anton-Culver, MW Beckmann, C Blomqvist, SE Bojesen, MK Bolla, B Bonanni, I Briceno, B Burwinkel, NJ Camp, JE Castelao, JY Choi
2022-09-01
Background: Predict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast ..
S Harlid, B Van Guelpen, C Qu, B Gylling, EK Aglago, EL Amitay, H Brenner, DD Buchanan, PT Campbell, Y Cao, AT Chan, J Chang-Claude, DA Drew, JC Figueiredo, AJ French, S Gallinger, M Giannakis, GG Giles, MJ Gunter, M Hoffmeister
2022-08-01
Diabetes is an established risk factor for colorectal cancer. However, colorectal cancer is a heterogeneous disease and it is not ..
Y Tian, AE Kim, SA Bien, Y Lin, C Qu, TA Harrison, R Carreras-Torres, V Díez-Obrero, N Dimou, DA Drew, A Hidaka, JR Huyghe, KM Jordahl, J Morrison, N Murphy, M Obón-Santacana, CM Ulrich, J Ose, AR Peoples, EA Ruiz-Narvaez
Background: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) ri..
MM Lane, M Lotfaliany, M Forbes, A Loughman, T Rocks, A O’Neil, P Machado, FN Jacka, A Hodge, W Marx
Background: Few studies have examined associations between ultra-processed food intake and biomarkers of inflammation, and inconsi..
SE Wang, SG Dashti, AM Hodge, SC Dixon-Suen, N Castaño-Rodríguez, RJS Thomas, GG Giles, RL Milne, A Boussioutas, BJ Kendall, DR English
Background: Mechanisms for how Helicobacter pylori infection respectively. No association was observed for women. H. pylori-affect..
JK Bassett, RJ MacInnis, Y Yang, AM Hodge, BM Lynch, DR English, GG Giles, RL Milne, H Jayasekara
2022-07-01
We examined associations between sex-specific alcohol intake trajectories and alcohol-related cancer risk using data from 22 756 w..
HA Robbins, A Ferreiro-Iglesias, T Waterboer, N Brenner, M Nygard, N Bender, L Schroeder, A Hildesheim, M Pawlita, G D'souza, K Visvanathan, H Langseth, NF Schlecht, LF Tinker, I Agalliu, S Wassertheil-Smoller, E Ness-Jensen, K Hveem, S Grioni, R Kaaks
2022-06-01
PURPOSESeropositivity for the HPV16-E6 oncoprotein is a promising marker for early detection of oropharyngeal cancer (OPC), but th..
SM Hussain, I Ackerman, Y Wang, D English, A Wluka, G Giles, S Graves, F Cicuttini
Background There is limited evidence regarding the association between trajectories of body mass index (BMI) across adulthood and ..
Y Huang, X Hua, JD Labadie, TA Harrison, JY Dai, S Lindstrom, Y Lin, SI Berndt, DD Buchanan, PT Campbell, G Casey, SJ Gallinger, MJ Gunter, M Hoffmeister, MA Jenkins, LC Sakoda, RE Schoen, B Diergaarde, ML Slattery, E White
2022-05-01
Elevated blood levels of C-reactive protein (CRP) have been linked to colorectal cancer (CRC) survival. We evaluated genetic varia..
J Steinberg, MM Iles, JY Lee, X Wang, MH Law, AK Smit, T Nguyen-Dumont, GG Giles, MC Southey, RL Milne, GJ Mann, DT Bishop, RJ MacInnis, AE Cust
Background: Previous studies suggest that polygenic risk scores (PRSs) may improve melanoma risk stratification. However, there ha..
MA Laaksonen, RJ MacInnis, K Canfell, JE Shaw, DJ Magliano, E Banks, GG Giles, JE Byles, TK Gill, P Mitchell, V Hirani, RG Cumming, CM Vajdic
2022-04-15
Thyroid cancer incidence and the prevalence of overweight and obesity are increasing, but the future thyroid cancer burden attribu..
PA Dugue, AM Hodge, A Ulvik, PM Ueland, O Midttun, S Rinaldi, RJ MacInnis, SX Li, K Meyer, AS Navionis, L Flicker, G Severi, DR English, P Vineis, GS Tell, MC Southey, RL Milne, GG Giles
2022-04-01
Background: Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially in..
F Morales-Berstein, DL McCartney, AT Lu, KK Tsilidis, E Bouras, P Haycock, K Burrows, AI Phipps, DD Buchanan, I Cheng, RM Martin, GD Smith, CL Relton, S Horvath, RE Marioni, TG Richardson, RC Richmond
2022-03-01
Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear ..
SE Wang, BJ Kendall, AM Hodge, SC Dixon-Suen, SG Dashti, E Makalic, EM Williamson, RJS Thomas, GG Giles, DR English
2022-01-01
We examined demographic and lifestyle risk factors for incidence of gastroesophageal reflux disease (GERD) and Barrett's esophagus..
C Yu, AM Hodge, EM Wong, JE Joo, E Makalic, DF Schmidt, DD Buchanan, G Severi, JL Hopper, DR English, GG Giles, RL Milne, MC Southey, PA Dugué
Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether ..
SEH Solvang, A Hodge, LO Watne, O Cabral-Marques, JE Nordrehaug, GG Giles, PA Dugué, O Nygård, PM Ueland, A Mccann, AV Idland, Ø Midttun, A Ulvik, NB Halaas, GS Tell, LM Giil
The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the ce..
N Mavaddat, L Dorling, S Carvalho, J Allen, A González-Neira, R Keeman, MK Bolla, J Dennis, Q Wang, TU Ahearn, IL Andrulis, MW Beckmann, S Behrens, J Benitez, M Bermisheva, C Blomqvist, NV Bogdanova, SE Bojesen, I Briceno, T Brüning
IMPORTANCE Rare germline genetic variants in several genes are associated with increased breast cancer (BC) risk, but their precis..
AM Hodge, MN Karim, JR Hébert, N Shivappa, RL Milne, B De Courten
2021-12-20
Objective: To ascertain which of the Alternative Healthy Eating Index (AHEI) 2010, Dietary Inflammatory Index (DII®) and Mediterra..
J Coignard, M Lush, J Beesley, TA O’Mara, J Dennis, JP Tyrer, DR Barnes, L McGuffog, G Leslie, MK Bolla, MA Adank, S Agata, T Ahearn, K Aittomäki, IL Andrulis, H Anton-Culver, V Arndt, N Arnold, KJ Aronson, BK Arun
2021-12-01
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants hav..
SM Hussain, Y Wang, AK Heath, GG Giles, DR English, DW Eyles, EJ Williamson, SE Graves, AE Wluka, FM Cicuttini
Background: To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteo..
C Yu, AM Hodge, EM Wong, JE Joo, E Makalic, D Schmidt, DD Buchanan, JL Hopper, GG Giles, MC Southey, PA Dugué
Genetic variants in FOXO3 are associated with longevity. Here, we assessed whether blood DNA methylation at FOXO3 was associated w..
A Morra, M Escala-Garcia, J Beesley, R Keeman, S Canisius, TU Ahearn, IL Andrulis, H Anton-Culver, V Arndt, PL Auer, A Augustinsson, LE Beane Freeman, H Becher, MW Beckmann, S Behrens, SE Bojesen, MK Bolla, H Brenner, T Brüning, SS Buys
Background: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival t..
M Suman, PA Dugué, EM Wong, JHE Joo, JL Hopper, T Nguyen-Dumont, GG Giles, RL Milne, C McLean, MC Southey
Background: Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognos..
H Zahed, M Johansson, PM Ueland, Ø Midttun, RL Milne, GG Giles, J Manjer, M Sandsveden, A Langhammer, EP Sørgjerd, K Grankvist, M Johansson, ND Freedman, WY Huang, C Chen, R Prentice, VL Stevens, Y Wang, L Le Marchand, LR Wilkens
Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population grou..
M Escala-Garcia, S Canisius, R Keeman, J Beesley, H Anton-Culver, V Arndt, A Augustinsson, H Becher, MW Beckmann, S Behrens, M Bermisheva, SE Bojesen, MK Bolla, H Brenner, F Canzian, JE Castelao, J Chang-Claude, SJ Chanock, FJ Couch, K Czene
Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with s..
AN Hurson, P Pal Choudhury, C Gao, A Hüsing, M Eriksson, M Shi, ME Jones, DGR Evans, RL Milne, MM Gaudet, CM Vachon, DI Chasman, DF Easton, MK Schmidt, P Kraft, M Garcia-Closas, N Chatterjee
Background: Rigorous evaluation of the calibration and discrimination of breast-cancer risk-prediction models in prospective cohor..
C Yu, KM Jordahl, JK Bassett, JE Joo, EM Wong, MT Brinkman, DF Schmidt, DM Bolton, E Makalic, TM Brasky, AH Shadyab, LF Tinker, A Longano, JL Hopper, DR English, RL Milne, P Bhatti, MC Southey, GG Giles, PA Dugue
Background: Self-reported information may not accurately capture smoking exposure. We aimed to evaluate whether smoking-associated..
EYW Yu, A Wesselius, S Mehrkanoon, M Goosens, M Brinkman, P van den Brandt, EJ Grant, E White, E Weiderpass, F Le Calvez-Kelm, MJ Gunter, I Huybrechts, E Riboli, A Tjonneland, G Masala, GG Giles, RL Milne, MP Zeegers
Background: Although a potential inverse association between vegetable intake and bladder cancer risk has been reported, epidemiol..
Julie K Bassett, Robert J MacInnis, Yi Yang, Allison M Hodge, Brigid M Lynch, Dallas R English, Graham G Giles, Roger L Milne, Harindra Jayasekara
2021-11-01
AM Hodge, MN Karim, JR Hébert, N Shivappa, B de Courten
Type 2 diabetes mellitus is a common condition whose incidence is increasing worldwide, and for which obesity and diet are importa..
A Nounu, RC Richmond, ID Stewart, P Surendran, NJ Wareham, A Butterworth, SJ Weinstein, D Albanes, JA Baron, JL Hopper, JC Figueiredo, PA Newcomb, NM Lindor, G Casey, EA Platz, LL Marchand, CM Ulrich, CI Li, FJB van Dujinhoven, A Gsur
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that r..
SE Wang, AM Hodge, SG Dashti, SC Dixon-Suen, H Mitchell, RJS Thomas, EM Williamson, E Makalic, A Boussioutas, AM Haydon, GG Giles, RL Milne, BJ Kendall, DR English
2021-10-21
Objective: To examine associations between diet and risk of developing gastro-oesophageal reflux disease (GERD). Design: Prospecti..
S Julián-Serrano, F Yuan, W Wheeler, B Benyamin, MJ Machiela, AA Arslan, LE Beane-Freeman, PM Bracci, EJ Duell, M Du, S Gallinger, GG Giles, PJ Goodman, C Kooperberg, LL Marchand, RE Neale, XO Shu, SK Van Den Eeden, K Visvanathan, W Zheng
2021-10-01
Background: Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic duct..
SX Li, AM Hodge, RJ MacInnis, JK Bassett, PM Ueland, Ø Midttun, A Ulvik, S Rinaldi, K Meyer, AS Navionis, N Shivappa, JR Hébert, L Flicker, G Severi, H Jayasekara, DR English, P Vineis, MC Southey, RL Milne, GG Giles
Background: Nutritional epidemiology research using self-reported dietary intake is prone to measurement error. Objective methods ..
SX Li, RL Milne, T Nguyen-Dumont, DR English, GG Giles, MC Southey, AC Antoniou, A Lee, I Winship, JL Hopper, MB Terry, RJ Macinnis
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated ..
H Jayasekara, RJ MacInnis, S Juneja, JK Bassett, F Bruinsma, BM Lynch, AM Hodge, JL Hopper, DR English, GG Giles, RL Milne
F Guida, VY Tan, LJ Corbin, K Smith-Byrne, K Alcala, C Langenberg, ID Stewart, AS Butterworth, P Surendran, D Achaintre, J Adamski, PA Exezarreta, MM Bergmann, CJ Bull, CC Dahm, A Gicquiau, GG Giles, MJ Gunter, T Haller, A Langhammer
2021-09-01
Background Excess bodyweight and related metabolic perturbations have : been implicated in kidney cancer aetiology, but the specif..
H Jayasekara, AM Hodge, A Haydon, R Room, JL Hopper, DR English, SA Smith-Warner, GG Giles, RL Milne, RJ MacInnis
2021-08-15
Alcohol consumption is a known cause of cancer, but its role in the etiology of second primary (metachronous) cancer is uncertain...
X Wang, E Amitay, TA Harrison, BL Banbury, SI Berndt, H Brenner, DD Buchanan, PT Campbell, Y Cao, AT Chan, J Chang-Claude, SJ Gallinger, M Giannakis, GG Giles, MJ Gunter, JL Hopper, MA Jenkins, Y Lin, V Moreno, R Nishihara
2021-08-01
Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted..
MA Laaksonen, K Canfell, RJ MacInnis, E Banks, JE Byles, GG Giles, DJ Magliano, JE Shaw, V Hirani, TK Gill, P Mitchell, RG Cumming, U Salagame, CM Vajdic
Background: Estimates of future burden of cancer attributable to current modifiable causal exposures can guide cancer prevention. ..
A Macauda, C Piredda, AI Clay-Gilmour, J Sainz, G Buda, M Markiewicz, T Barington, E Ziv, MAT Hildebrandt, AA Belachew, J Varkonyi, W Prejzner, A Druzd-Sitek, J Spinelli, NF Andersen, JN Hofmann, M Dudziński, J Martinez-Lopez, E Iskierka-Jazdzewska, RL Milne
2021-07-15
Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit f..
X Hua, JY Dai, S Lindstrom, TA Harrison, Y Lin, SR Alberts, E Alwers, SI Berndt, H Brenner, DD Buchanan, PT Campbell, G Casey, J Chang-Claude, S Gallinger, GG Giles, RM Goldberg, MJ Gunter, M Hoffmeister, MA Jenkins, AD Joshi
2021-07-01
Background: A positive association between circulating Creactive protein (CRP) and colorectal cancer survival was reported in obse..
Niki Dimou, Andre E Kim, Orlagh Flanagan, Neil Murphy, Emmanouil Bouras, Peter T Campbell, Graham Casey, Steven Gallinger, Stephen B Gruber, Li Hsu, Mark A Jenkins, Yi Lin, Victor Moreno, Conghui Qu, Edward Ruiz-Narvaez, Mariana C Stern, Yu Tian, Kostas Tsilidis, W James Gauderman, Marc J Gunter
JE Joo, M Clendenning, EM Wong, C Rosty, K Mahmood, P Georgeson, IM Winship, SG Preston, AK Win, PA Dugué, H Jayasekara, D English, FA Macrae, JL Hopper, MA Jenkins, RL Milne, GG Giles, MC Southey, DD Buchanan
2021-06-01
We investigated aberrant DNA methylation (DNAm) changes and the contribution of ageing-associated methylomic drift and age acceler..
H Jayasekara, RJ MacInnis, L Lujan-Barroso, AL Mayen-Chacon, AJ Cross, B Wallner, D Palli, F Ricceri, V Pala, S Panico, R Tumino, T Kühn, R Kaaks, K Tsilidis, MJ Sánchez, P Amiano, E Ardanaz, MD Chirlaque López, S Merino, JA Rothwell
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the a..
SX Li, RL Milne, T Nguyen-Dumont, X Wang, DR English, GG Giles, MC Southey, AC Antoniou, A Lee, S Li, I Winship, JL Hopper, MB Terry, RJ MacInnis
Background: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Can..
LM Hurwitz, I Agalliu, D Albanes, KH Barry, SI Berndt, Q Cai, C Chen, I Cheng, JM Genkinger, GG Giles, J Huang, CE Joshu, TJ Key, S Knutsen, S Koutros, H Langseth, SX Li, RJ MacInnis, SC Markt, KL Penney
Background: In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome..
E Mocci, P Kundu, W Wheeler, AA Arslan, LE Beane-Freeman, PM Bracci, P Brennan, F Canzian, M Du, S Gallinger, GG Giles, PJ Goodman, C Kooperberg, L Le Marchand, RE Neale, XO Shu, K Visvanathan, E White, W Zheng, D Albanes
Germline variation and smoking are independently associated with pancreatic ductal adenocarcinoma (PDAC). We conducted genome-wide..
JY Park, JY Choi, J Choi, S Chung, N Song, SK Park, W Han, DY Noh, SH Ahn, JW Lee, MK Kim, SH Jee, W Wen, MK Bolla, Q Wang, J Dennis, K Michailidou, M Shah, DM Conroy, PA Harrington
2021-05-02
In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environme..
TL Nguyen, DF Schmidt, E Makalic, G Maskarinec, S Li, GS Dite, YK Aung, CF Evans, HN Trinh, L Baglietto, J Stone, YM Song, J Sung, RJ MacInnis, PA Dugué, JG Dowty, MA Jenkins, RL Milne, MC Southey, GG Giles
2021-05-01
Mammograms contain information that predicts breast cancer risk. We developed two novel mammogram-based breast cancer risk measure..
C Yu, EM Wong, JE Joo, AM Hodge, E Makalic, D Schmidt, DD Buchanan, G Severi, JL Hopper, DR English, GG Giles, MC Southey, PA Dugué
2021-04-02
To investigate age-and sex-specific DNA methylation alterations related to cancer risk and survival, we used matched case–control ..
A Morra, AY Jung, S Behrens, R Keeman, TU Ahearn, H Anton-Culver, V Arndt, A Augustinsson, PK Auvinen, LE Beane Freeman, H Becher, MW Beckmann, C Blomqvist, SE Bojesen, MK Bolla, H Brenner, I Briceno, SY Brucker, NJ Camp, D Campa
2021-04-01
Background: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subt..
NL Dimou, N Papadimitriou, D Mariosa, M Johansson, P Brennan, U Peters, SJ Chanock, M Purdue, DT Bishop, M Gago-Dominquez, GG Giles, V Moreno, EA Platz, CM Tangen, A Wolk, W Zheng, X Wu, PT Campbell, E Giovannucci, Y Lin
Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental ..
S Sajeev, S Champion, A Beleigoli, D Chew, RL Reed, DJ Magliano, JE Shaw, RL Milne, S Appleton, TK Gill, A Maeder
2021-03-02
Effective cardiovascular disease (CVD) prevention relies on timely identification and intervention for individuals at risk. Conven..
A Nounu, A Greenhough, KJ Heesom, RC Richmond, J Zheng, SJ Weinstein, D Albanes, JA Baron, JL Hopper, JC Figueiredo, PA Newcomb, NM Lindor, G Casey, EA Platz, L Le Marchand, CM Ulrich, CI Li, FJB van Duijnhoven, A Gsur, PT Campbell
2021-03-01
Background: Evidence for aspirin’s chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of ac..
PM Kapoor, N Mavaddat, PP Choudhury, AN Wilcox, S Lindström, S Behrens, K Michailidou, J Dennis, MK Bolla, Q Wang, A Jung, Z Abu-Ful, T Ahearn, IL Andrulis, H Anton-Culver, V Arndt, KJ Aronson, PL Auer, LEB Freeman, H Becher
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for ..
DJ Schaid, SK McDonnell, LM FitzGerald, L DeRycke, Z Fogarty, GG Giles, RJ MacInnis, MC Southey, T Nguyen-Dumont, G Cancel-Tassin, O Cussenot, AS Whittemore, W Sieh, NM Ioannidis, CL Hsieh, JL Stanford, J Schleutker, CD Cropp, J Carpten, J Hoegel
Background: Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are ass..
PA Dugué, C Yu, T McKay, EM Wong, JE Joo, H Tsimiklis, F Hammet, M Mahmoodi, D Theys, null Kconfab, JL Hopper, GG Giles, RL Milne, JA Steen, JG Dowty, T Nguyen‐dumont, MC Southey
VTRNA2‐1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associa..
PA Dugue, JK Bassett, EM Wong, JHE Joo, S Li, C Yu, DF Schmidt, E Makalic, NW Doo, DD Buchanan, AM Hodge, DR English, JL Hopper, GG Giles, MC Southey, RL Milne
2021-02-01
Background: We previously investigated the association between 5 "first-generation"measures of epigenetic aging and cancer risk in..
JA Chamberlain, PA Dugué, JK Bassett, RL Milne, JE Joo, EM Wong, MT Brinkman, GW Stuart, A Boussioutas, MC Southey, GG Giles, H Mitchell, DR English, AM Hodge
DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..
Y Yang, BM Lynch, PA Dugue, A Karahalios, RJ MacInnis, JK Bassett, A McAleese, C Sinclair, GG Giles, RL Milne, AM Hodge, DR English
Background: Obesity increases the risk of 13 cancer types. Given the long process of carcinogenesis, it is important to determine ..
PA Dugué, AM Hodge, EM Wong, JE Joo, CH Jung, JL Hopper, DR English, GG Giles, RL Milne, MC Southey
Background: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldo..
PF Kho, F Amant, D Annibali, K Ashton, J Attia, PL Auer, MW Beckmann, A Black, L Brinton, DD Buchanan, SJ Chanock, C Chen, MM Chen, THT Cheng, LS Cook, M Crous-Bous, K Czene, I De Vivo, J Dennis, T Dörk
2021-01-15
Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For en..
PA Dugué, R Wilson, B Lehne, H Jayasekara, X Wang, CH Jung, JHE Joo, E Makalic, DF Schmidt, L Baglietto, G Severi, C Gieger, KH Ladwig, A Peters, JS Kooner, MC Southey, DR English, M Waldenberger, JC Chambers, GG Giles
2021-01-01
DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a l..
A Moore, MJ Machiela, M Machado, SS Wang, E Kane, SL Slager, W Zhou, M Carrington, Q Lan, RL Milne, BM Birmann, HO Adami, D Albanes, AA Arslan, N Becker, Y Benavente, S Bisanzi, P Boffetta, PM Bracci, P Brennan
Aim: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), def..
Pierre-Antoine Dugué, Chenglong Yu, Allison Hodge, Ee Ming Wong, JiHoon Joo, Chol-Hee Jung, Daniel Schmidt, Enes Makalic, Daniel Buchanan, Gianluca Severi, Dallas English, John Hopper, Roger Milne, Graham Giles, Melissa Southey
<h4>ABSTRACT</h4> Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better c..
YZ Lim, Y Wang, FM Cicuttini, GG Giles, S Graves, AE Wluka, SM Hussain
Objective To examine the risk of total knee arthroplasty (TKA) due to osteoarthritis associated with obesity defined by body mass ..
JD Labadie, TA Harrison, B Banbury, EL Amtay, S Bernd, H Brenner, DD Buchanan, PT Campbell, Y Cao, AT Chan, J Chang-Claude, D Englishc, JC Figueiredo, SJ Gallingerc, GG Gilesc, MJ Gunter, M Hoffmeisterc, L Hsu, MA Jenkins, Y Lin
Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogen..
CJ Bull, JA Bell, N Murphy, E Sanderson, G Davey Smith, NJ Timpson, BL Banbury, D Albanes, SI Berndt, S Bézieau, DT Bishop, H Brenner, DD Buchanan, A Burnett-Hartman, G Casey, S Castellví-Bel, AT Chan, J Chang-Claude, AJ Cross, A de la Chapelle
2020-12-01
Background: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub..
M Escala-Garcia, J Abraham, IL Andrulis, H Anton-Culver, V Arndt, A Ashworth, PL Auer, P Auvinen, MW Beckmann, J Beesley, S Behrens, J Benitez, M Bermisheva, C Blomqvist, W Blot, NV Bogdanova, SE Bojesen, MK Bolla, AL Børresen-Dale, H Brauch
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-base..
J Foreman, M McGuinness, DA Mackey, P van Wijngaarden
S Li, TL Nguyen, EM Wong, PA Dugué, GS Dite, NJ Armstrong, JM Craig, KA Mather, PS Sachdev, R Saffery, J Sung, Q Tan, A Thalamuthu, RL Milne, GG Giles, MC Southey, JL Hopper
Background: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..
S Neumeyer, X Hua, P Seibold, L Jansen, A Benner, B Burwinkel, N Halama, SI Berndt, AI Phipps, LC Sakoda, RE Schoen, ML Slattery, AT Chan, M Gala, AD Joshi, S Ogino, M Song, E Herpel, H Blaker, M Kloor
Background: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..
J Liu, WJC Prager - van der Smissen, JM Collée, MK Bolla, Q Wang, K Michailidou, J Dennis, TU Ahearn, K Aittomäki, CB Ambrosone, IL Andrulis, H Anton-Culver, NN Antonenkova, V Arndt, N Arnold, KJ Aronson, A Augustinsson, P Auvinen, H Becher, MW Beckmann
In breast cancer, high levels of homeobox protein Hox-B13 (HOXB13) have been associated with disease progression of ER-positive br..
EYW Yu, A Wesselius, S Mehrkanoon, M Brinkman, P Van Den Brandt, E White, E Weiderpass, F Le Calvez-Kelm, M Gunter, I Huybrechts, F Liedberg, G Skeie, A Tjonneland, E Riboli, GG Giles, RL Milne, MP Zeegers
2020-11-01
Background: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsu..
Akihisa Hidaka, Tabitha A Harrison, Yin Cao, Lori C Sakoda, Richard Barfield, Marios Giannakis, Mingyang Song, Amanda Phipps, Jane C Figueiredo, Syed H Zaidi, Amanda E Toland, Efrat L Amitay, Sonja Berndt, Ivan Borozan, Andrew T Chan, Steven Gallinger, Marc J Gunter, Mark A Guinter, Sophia Harlid, Heather Hampel
2020-10-15
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all e..
SS Jackson, HO Adami, G Andreotti, LE Beane-Freeman, AB de González, JE Buring, GE Fraser, ND Freedman, SM Gapstur, G Gierach, GG Giles, F Grodstein, P Hartge, M Jenab, V Kirsh, SF Knutsen, Q Lan, SC Larsson, IM Lee, MH Lee
2020-10-01
Background & Aims: Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a..
CTV Swain, JK Bassett, AM Hodge, FJ Bruinsma, S Mahmood, H Jayasekara, RJ MacInnis, GG Giles, RL Milne, DR English, BM Lynch
Purpose Using the Melbourne Collaborative Cohort Study, we examined the associations of occupation, household, transport, and leis..
RT Fortner, MS Rice, SF Knutsen, MJ Orlich, K Visvanathan, AV Patel, MM Gaudet, A Tjønneland, M Kvaskoff, R Kaaks, A Trichopolou, V Pala, N Charlotte Onland-Moret, IT Gram, P Amiano, A Idahl, NE Allen, E Weiderpass, JN Poynter, K Robien
Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies hav..
A Gagliardi, PA Dugue, TH Nøst, MC Southey, DD Buchanan, DF Schmidt, E Makalic, AM Hodge, DR English, NW Doo, JL Hopper, G Severi, L Baglietto, A Naccarati, S Tarallo, L Pace, V Krogh, D Palli, S Panico, C Sacerdote
Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..
F Yuan, RJ Hung, N Walsh, H Zhang, EA Platz, W Wheeler, L Song, AA Arslan, LE Beane Freeman, P Bracci, F Canzian, M Du, S Gallinger, GG Giles, PJ Goodman, C Kooperberg, L Le Marchand, RE Neale, J Rosendahl, G Scelo
2020-09-15
Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal a..
MJ Schoemaker, HB Nichols, LB Wright, MN Brook, ME Jones, KM O'Brien, HO Adami, L Baglietto, L Bernstein, KA Bertrand, MC Boutron-Ruault, Y Chen, AE Connor, L Dossus, AH Eliassen, GG Giles, IT Gram, SE Hankinson, R Kaaks, TJ Key
2020-09-01
Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequ..
X Wang, YR Su, PS Petersen, S Bien, SL Schmit, DA Drew, D Albanes, SI Berndt, H Brenner, PT Campbell, G Casey, J Chang-Claude, SJ Gallinger, SB Gruber, RW Haile, TA Harrison, M Hoffmeister, EJ Jacobs, MA Jenkins, AD Joshi
Background: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome..
H Tang, L Jiang, RZ Stolzenberg-Solomon, AA Arslan, LE Beane Freeman, PM Bracci, P Brennan, F Canzian, M Du, S Gallinger, GG Giles, PJ Goodman, C Kooperberg, L Le Marchand, RE Neale, XO Shu, K Visvanathan, E White, W Zheng, D Albanes
Background: Obesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants an..
LR Teras, AV Patel, M Wang, SS Yaun, K Anderson, R Brathwaite, BJ Caan, Y Chen, AE Connor, AH Eliassen, SM Gapstur, MM Gaudet, JM Genkinger, GG Giles, IM Lee, RL Milne, K Robien, N Sawada, HD Sesso, MJ Stampfer
Background: Excess body weight is an established cause of postmenopausal breast cancer, but it is unknown if weight loss reduces r..
A Beeghly-Fadiel, NK Khankari, RJ Delahanty, XO Shu, Y Lu, MK Schmidt, MK Bolla, K Michailidou, Q Wang, J Dennis, D Yannoukakos, AM Dunning, PDP Pharoah, G Chenevix-Trench, RL Milne, DJ Hunter, H Per, P Kraft, J Simard, DF Easton
2020-08-01
Background: Conventional epidemiologic studies have evaluated associations between circulating lipid levels and breast cancer risk..
Z Wu, NH Nguyen, D Wang, BM Lynch, AM Hodge, JK Bassett, VM White, R Borland, DR English, RL Milne, GG Giles, PA Dugué
Men with prostate cancer experience side effects for which a supportive social environment may be beneficial. We examined the asso..
D Zhu, HF Chung, AJ Dobson, N Pandeya, EJ Brunner, D Kuh, DC Greenwood, R Hardy, JE Cade, GG Giles, F Bruinsma, P Demakakos, MK Simonsen, S Sandin, E Weiderpass, GD Mishra
STUDY QUESTION: How does the risk of cardiovascular disease (CVD) vary with type and age of menopause? SUMMARY ANSWER: Earlier sur..
TL Nguyen, S Li, GS Dite, YK Aung, CF Evans, HN Trinh, L Baglietto, J Stone, YM Song, J Sung, DR English, MA Jenkins, PA Dugué, RL Milne, MC Southey, GG Giles, MC Pike, JL Hopper
2020-07-15
Interval breast cancers (those diagnosed between recommended mammography screens) generally have poorer outcomes and are more comm..
H Feng, A Gusev, B Pasaniuc, L Wu, J Long, Z Abu-full, K Aittomäki, IL Andrulis, H Anton-Culver, AC Antoniou, A Arason, V Arndt, KJ Aronson, BK Arun, E Asseryanis, PL Auer, J Azzollini, J Balmaña, RB Barkardottir, DR Barnes
2020-07-01
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expressio..
AI Clay-Gilmour, MAT Hildebrandt, EE Brown, JN Hofmann, JJ Spinelli, GG Giles, W Cozen, P Bhatti, X Wu, RG Waller, AA Belachew, DP Robinson, AD Norman, JP Sinnwell, SI Berndt, SV Rajkumar, SK Kumar, SJ Chanock, MJ Machiela, RL Milne
2020-06-23
So far, 23 germline susceptibility loci have been associated with multiple myeloma (MM) risk. It is unclear whether the genetic va..
JK Bassett, RL Milne, DR English, GG Giles, AM Hodge
2020-06-15
Consumption of sugary drinks increases the risk of obesity. Previously, we reported a positive association between sugar-sweetened..
AI Phipps, E Alwers, T Harrison, B Banbury, H Brenner, PT Campbell, J Chang-Claude, D Buchanan, AT Chan, AB Farris, JC Figueiredo, S Gallinger, GG Giles, M Jenkins, RL Milne, PA Newcomb, ML Slattery, M Song, S Ogino, SH Zaidi
2020-06-01
Background and Aims: The heterogeneity among colorectal tumors is probably due to differences in developmental pathways and might ..
F Imamura, AM Fretts, M Marklund, AV Ardisson Korat, WS Yang, M Lankinen, W Qureshi, C Helmer, TA Chen, JK Virtanen, K Wong, JK Bassett, R Murphy, N Tintle, CI Yu, IA Brouwer, KL Chien, YY Chen, AC Wood, LC del Gobbo
Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alc..
JY Huang, TL Larose, HN Luu, R Wang, A Fanidi, K Alcala, VL Stevens, SJ Weinstein, D Albanes, NE Caporaso, MP Purdue, RG Ziegler, ND Freedman, Q Lan, RL Prentice, M Pettinger, CA Thomson, Q Cai, J Wu, WJ Blot
2020-05-01
Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulati..
Z Xia, YR Su, P Petersen, L Qi, AE Kim, JC Figueiredo, Y Lin, H Nan, LC Sakoda, D Albanes, SI Berndt, S Bézieau, S Bien, DD Buchanan, G Casey, AT Chan, DV Conti, DA Drew, SJ Gallinger, WJ Gauderman
Background: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbati..
G Kleinstern, NJ Camp, SI Berndt, BM Birmann, A Nieters, PM Bracci, JD McKay, H Ghesquieres, Q Lan, H Hjalgrim, Y Benavente, A Monnereau, SS Wang, Y Zhang, MP Purdue, A Zeleniuch-Jacquotte, GG Giles, R Vermeulen, P Cocco, D Albanes
Background: Lipid traits have been inconsistently linked to risk of non-Hodgkin lymphoma (NHL). We examined the association of gen..
PA Dugué, CH Jung, JE Joo, X Wang, EM Wong, E Makalic, DF Schmidt, L Baglietto, G Severi, MC Southey, DR English, GG Giles, RL Milne
2020-04-02
We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication of previously discovered ..
AK Heath, AM Hodge, PR Ebeling, D Kvaskoff, DW Eyles, GG Giles, DR English, EJ Williamson
2020-04-01
Vitamin D deficiency is associated with higher all-cause mortality, but associations with specific causes of death are unclear. We..
N Murphy, R Carreras-Torres, M Song, AT Chan, RM Martin, N Papadimitriou, N Dimou, KK Tsilidis, B Banbury, KE Bradbury, J Besevic, S Rinaldi, E Riboli, AJ Cross, RC Travis, C Agnoli, D Albanes, SI Berndt, S Bézieau, DT Bishop
Background & Aims: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insu..
AN Archambault, YR Su, J Jeon, M Thomas, Y Lin, DV Conti, AK Win, LC Sakoda, I Lansdorp-Vogelaar, EFP Peterse, AG Zauber, D Duggan, AN Holowatyj, JR Huyghe, H Brenner, M Cotterchio, S Bézieau, SL Schmit, CK Edlund, MC Southey
Background & Aims: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in t..
SG Dashti, JA Simpson, A Karahalios, V Viallon, M Moreno-Betancur, LC Gurrin, RJ MacInnis, BM Lynch, L Baglietto, HA Morris, MJ Gunter, P Ferrari, RL Milne, GG Giles, DR English
2020-03-15
Adiposity increases estrogen receptor (ER)-positive postmenopausal breast cancer risk. While mechanisms underlying this relationsh..
B Trabert, SS Tworoger, KM O'Brien, MK Townsend, RT Fortner, ES Iversen, P Hartge, E White, P Amiano, AA Arslan, L Bernstein, LA Brinton, JE Buring, L Dossus, GE Fraser, MM Gaudet, GG Giles, IT Gram, HR Harris, JH Bolton
2020-03-01
Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube..
John L Hopper, Tuong L Nguyen, Daniel F Schmidt, Enes Makalic, Yun-Mi Song, Joohon Sung, Gillian S Dite, James G Dowty, Shuai Li
2020-02-26
This commentary is about predicting a woman's breast cancer risk from her mammogram, building on the work of Wolfe, Boyd and Yaffe..
S Mahmood, NH Nguyen, JK Bassett, RJ Macinnis, A Karahalios, N Owen, FJ Bruinsma, RL Milne, GG Giles, DR English, BM Lynch
2020-02-01
Background: Self-reported physical activity is inaccurate, yet few investigators attempt to adjust for measurement error when esti..
PM Kapoor, S Lindström, S Behrens, X Wang, K Michailidou, MK Bolla, Q Wang, J Dennis, AM Dunning, PDP Pharoah, MK Schmidt, P Kraft, M García-Closas, DF Easton, RL Milne, J Chang-Claude
Background: Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Usi..
S McNabb, TA Harrison, D Albanes, SI Berndt, H Brenner, BJ Caan, PT Campbell, Y Cao, J Chang-Claude, A Chan, Z Chen, DR English, GG Giles, EL Giovannucci, PJ Goodman, RB Hayes, M Hoffmeister, EJ Jacobs, AD Joshi, SC Larsson
Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported e..
MA Laaksonen, RJ MacInnis, K Canfell, GG Giles, P Hull, JE Shaw, RG Cumming, TK Gill, E Banks, P Mitchell, JE Byles, DJ Magliano, V Hirani, D Connah, CM Vajdic
Substantial changes in the prevalence of the principal kidney and bladder cancer risk factors, smoking (both cancers) and body fat..
A Moore, E Kane, Z Wang, OA Panagiotou, LR Teras, A Monnereau, N Wong Doo, MJ Machiela, CF Skibola, SL Slager, G Salles, NJ Camp, PM Bracci, A Nieters, RCH Vermeulen, J Vijai, KE Smedby, Y Zhang, CM Vajdic, W Cozen
2020-01-28
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an i..
NK Khankari, BL Banbury, MC Borges, P Haycock, D Albanes, V Arndt, SI Berndt, S Bézieau, null Hermann Brenner, PT Campbell, G Casey, AT Chan, J Chang-Claude, DV Conti, M Cotterchio, DR English, JC Figueiredo, GG Giles, EL Giovannucci, MJ Gunter
2020-01-01
Background: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsi..
PA Dugué, JA Chamberlain, JK Bassett, AM Hodge, MT Brinkman, JHE Joo, CH Jung, EM Wong, E Makalic, DF Schmidt, JL Hopper, DD Buchanan, DR English, RL Milne, MC Southey, GG Giles
T Huang, MK Townsend, N Wentzensen, B Trabert, E White, AA Arslan, E Weiderpass, JE Buring, TV Clendenen, GG Giles, IM Lee, RL Milne, N Charlotte Onland-Moret, U Peters, DP Sandler, LJ Schouten, PA van den Brandt, A Wolk, A Zeleniuch-Jacquotte, SS Tworoger
Background: Laterality of epithelial ovarian tumors may reflect the underlying carcinogenic pathways and origins of tumor cells. M..
CMY Lee, S Colagiuri, M Woodward, EW Gregg, R Adams, F Azizi, R Gabriel, TK Gill, C Gonzalez, A Hodge, DR Jacobs, JJ Joseph, D Khalili, DJ Magliano, K Mehlig, R Milne, G Mishra, M Mongraw-Chaffin, JA Pasco, M Sakurai
2019-12-29
Objective There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conve..
EJ Williamson, J Polak, JA Simpson, GG Giles, DR English, A Hodge, L Gurrin, AB Forbes
2019-12-26
Background: Adherence to a traditional Mediterranean diet has been associated with lower mortality and cardiovascular disease risk..
MB McGuinness, J Kasza, A Karahalios, RH Guymer, RP Finger, JA Simpson
2019-12-03
Background: Attrition due to death and non-attendance are common sources of bias in studies of age-related diseases. A simulation ..
M Chen, EM Wong, TL Nguyen, GS Dite, J Stone, PA Dugué, GG Giles, MC Southey, RL Milne, JL Hopper, S Li
2019-12-01
DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict bre..
T Dörk, P Peterlongo, A Mannermaa, MK Bolla, Q Wang, J Dennis, T Ahearn, IL Andrulis, H Anton-Culver, V Arndt, KJ Aronson, A Augustinsson, LEB Freeman, MW Beckmann, A Beeghly-Fadiel, S Behrens, M Bermisheva, C Blomqvist, NV Bogdanova, SE Bojesen
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, mono..
S Keel, Z Li, J Scheetz, L Robman, J Phung, G Makeyeva, KZ Aung, C Liu, X Yan, W Meng, R Guymer, R Chang, M He
2019-11-01
Importance: Detection of early onset neovascular age-related macular degeneration (AMD) is critical to protecting vision. Backgrou..
ME Arriaga, CM Vajdic, K Canfell, RJ MacInnis, E Banks, JE Byles, DJ Magliano, AW Taylor, P Mitchell, GG Giles, JE Shaw, TK Gill, E Klaes, LS Velentzis, RG Cumming, V Hirani, MA Laaksonen
Estimates of the future breast cancer burden preventable through modifications to current behaviours are lacking. We assessed the ..
L Din, M Sheikh, N Kosaraju, KE Smedby, S Bernatsky, SI Berndt, CF Skibola, A Nieters, S Wang, JD McKay, P Cocco, M Maynadié, L Foretová, A Staines, TM Mack, S de Sanjosé, TJ Vyse, L Padyukov, A Monnereau, AA Arslan
2019-10-01
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a comb..
S Li, PA Dugué, L Baglietto, G Severi, EM Wong, TL Nguyen, J Stone, DR English, MC Southey, GG Giles, JL Hopper, RL Milne
Age- and body mass index (BMI)-adjusted mammographic density is one of the strongest breast cancer risk factors. DNA methylation i..
SS Jackson, AL Van Dyke, B Zhu, RM Pfeiffer, JL Petrick, HO Adami, D Albanes, G Andreotti, LE Beane Freeman, AB De Gonzalez, JE Buring, AT Chan, Y Chen, GE Fraser, ND Freedman, YT Gao, SM Gapstur, J Michael Gaziano, GG Giles, EJ Grant
2019-08-01
Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors f..
AR Kreimer, A Ferreiro-Iglesias, M Nygard, N Bender, L Schroeder, A Hildesheim, HA Robbins, M Pawlita, H Langseth, NF Schlecht, LF Tinker, I Agalliu, SW Smoller, E Ness-Jensen, K Hveem, G D'Souza, K Visvanathan, B May, G Ursin, E Weiderpass
Background: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority..
Y Yang, PA Dugué, BM Lynch, AM Hodge, A Karahalios, RJ MacInnis, RL Milne, GG Giles, DR English
Objective Limited research has assessed the association between patterns of body mass index (BMI) change across adulthood and mort..
SA Bien, YR Su, DV Conti, TA Harrison, C Qu, X Guo, Y Lu, D Albanes, PL Auer, BL Banbury, SI Berndt, S Bézieau, H Brenner, DD Buchanan, BJ Caan, PT Campbell, CS Carlson, AT Chan, J Chang-Claude, S Chen
2019-07-01
Every author has erroneously been assigned to the affiliation “62”. The affiliation 62 belongs to the author Graham Casey.
RT Fortner, EM Poole, NA Wentzensen, B Trabert, E White, AA Arslan, AV Patel, VW Setiawan, K Visvanathan, E Weiderpass, HO Adami, A Black, L Bernstein, LA Brinton, J Buring, TV Clendenen, A Fournier, G Fraser, SM Gapstur, MM Gaudet
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothe..
X Wang, JY Dai, D Albanes, V Arndt, SI Berndt, S Bézieau, H Brenner, DD Buchanan, K Butterbach, B Caan, G Casey, PT Campbell, AT Chan, Z Chen, J Chang-Claude, M Cotterchio, DF Easton, GG Giles, E Giovannucci, WM Grady
2019-06-01
Background: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also modera..
MA Laaksonen, ME Arriaga, K Canfell, RJ MacInnis, JE Byles, E Banks, JE Shaw, P Mitchell, GG Giles, DJ Magliano, TK Gill, E Klaes, LS Velentzis, V Hirani, RG Cumming, CM Vajdic
Objective: Evidence on the endometrial and ovarian cancer burden preventable through modifications to current causal behavioural a..
CM Vachon, CG Scott, RM Tamimi, DJ Thompson, PA Fasching, J Stone, MC Southey, S Winham, S Lindström, J Lilyquist, GG Giles, RL Milne, RJ MacInnis, L Baglietto, J Li, K Czene, MK Bolla, Q Wang, J Dennis, L Haeberle
2019-05-22
Background: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of comm..
PA Dugué, JK Bassett, MT Brinkman, MC Southey, JE Joo, EM Wong, RL Milne, DR English, GG Giles, A Boussioutas, H Mitchell, AM Hodge
2019-05-19
Dietary intakes of B vitamins and other components involved in one-carbon metabolism, which is necessary for DNA replication, DNA ..
S Kim, M Wang, JP Tyrer, A Jensen, A Wiensch, G Liu, AW Lee, RB Ness, M Salvatore, SS Tworoger, AS Whittemore, H Anton-Culver, W Sieh, SH Olson, A Berchuck, EL Goode, MT Goodman, JA Doherty, G Chenevix-Trench, MA Rossing
2019-05-01
As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study consid..
AK Heath, AM Hodge, PR Ebeling, DW Eyles, D Kvaskoff, DD Buchanan, GG Giles, EJ Williamson, DR English
Background: The role of vitamin D in cancer risk remains controversial, and limited data exist on associations between vitamin D a..
A Johansson, D Palli, G Masala, S Grioni, C Agnoli, R Tumino, MC Giurdanella, F Fasanelli, C Sacerdote, S Panico, A Mattiello, S Polidoro, ME Jones, MJ Schoemaker, N Orr, K Tomczyk, N Johnson, O Fletcher, V Perduca, L Baglietto
2019-04-30
Background: It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesiz..
JK Bassett, MT Brinkman, PA Dugué, PM Ueland, Ø Midttun, A Ulvik, D Bolton, MC Southey, DR English, RL Milne, AM Hodge, GG Giles
2019-04-15
B-group vitamins, as components of the one carbon metabolism pathway, are involved in DNA synthesis, repair and methylation. Our a..
H Jayasekara, DR English, AM Hodge, R Room, JL Hopper, RL Milne, GG Giles, RJ MacInnis
Purpose: Pancreatic cancer has one of the worst prognoses with 5-year survival below 10%. There is some evidence that alcohol cons..
G Fiorito, C McCrory, O Robinson, C Carmeli, CO Rosales, Y Zhang, E Colicino, PA Dugué, F Artaud, GJ McKay, A Jeong, PP Mishra, TH Nøst, V Krogh, S Panico, C Sacerdote, R Tumino, D Palli, G Matullo, S Guarrera
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of ..
JE Joo, H Jayasekara, EM Wong, M Clendenning, C Rosty, IM Winship, MA Jenkins, JL Hopper, DR English, RL Milne, GG Giles, MC Southey, DD Buchanan
2019-04-01
Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are..
M Escala-Garcia, Q Guo, T Dörk, S Canisius, R Keeman, J Dennis, J Beesley, J Lecarpentier, MK Bolla, Q Wang, J Abraham, IL Andrulis, H Anton-Culver, V Arndt, PL Auer, MW Beckmann, S Behrens, J Benitez, M Bermisheva, L Bernstein
2019-03-19
Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of wome..
EH Van Roekel, PA Dugué, CH Jung, JE Joo, E Makalic, EM Wong, DR English, MC Southey, GG Giles, BM Lynch, RL Milne
2019-03-01
Introduction Physical activity may affect health via DNA methylation. The epigenetic influences of sedentary behaviors such as tel..
ME Arriaga, CM Vajdic, RJ MacInnis, K Canfell, DJ Magliano, JE Shaw, JE Byles, GG Giles, AW Taylor, TK Gill, V Hirani, RG Cumming, RP Mitchell, E Banks, J Marker, BA Adelstein, MA Laaksonen
Objective: To estimate the burden of pancreatic cancer in Australia attributable to modifiable exposures, particularly smoking. De..
AK Heath, EJ Williamson, AM Hodge, PR Ebeling, DW Eyles, D Kvaskoff, K O'Dea, GG Giles, DR English
Aims: Inverse associations between vitamin D status and risk of type 2 diabetes observed in epidemiological studies could be biase..
Y Yang, L Wu, X Shu, Y Lu, XO Shu, Q Cai, A Beeghly-Fadiel, B Li, F Ye, A Berchuck, H Anton-Culver, S Banerjee, J Benitez, L Bjørge, JD Brenton, R Butzow, IG Campbell, J Chang-Claude, K Chen, LS Cook
2019-02-01
DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark..
SL Schmit, CK Edlund, FR Schumacher, J Gong, TA Harrison, JR Huyghe, C Qu, M Melas, DJ Van Den Berg, H Wang, S Tring, SJ Plummer, D Albanes, MH Alonso, CI Amos, K Anton, AK Aragaki, V Arndt, EL Barry, SI Berndt
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10<sup>-8</sup>) associated with risk..
HB Nichols, MJ Schoemaker, J Cai, J Xu, LB Wright, MN Brook, ME Jones, HO Adami, L Baglietto, KA Bertrand, WJ Blot, MC Boutron-Ruault, M Dorronsoro, L Dossus, AH Eliassen, GG Giles, IT Gram, SE Hankinson, J Hoffman-Bolton, R Kaaks
2019-01-01
Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after chi..
TL Nguyen, YK Aung, S Li, NH Trinh, CF Evans, L Baglietto, K Krishnan, GS Dite, J Stone, DR English, YM Song, J Sung, MA Jenkins, MC Southey, GG Giles, JL Hopper
2018-12-13
Background: Case-control studies show that mammographic density is a better risk factor when defined at higher than conventional p..
AP Klein, BM Wolpin, HA Risch, RZ Stolzenberg-Solomon, E Mocci, M Zhang, F Canzian, EJ Childs, JW Hoskins, A Jermusyk, J Zhong, F Chen, D Albanes, G Andreotti, AA Arslan, A Babic, WR Bamlet, L Beane-Freeman, SI Berndt, A Blackford
2018-12-01
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify comm..
AJ Rodríguez, D Scott, B Khan, A Hodge, DR English, GG Giles, B Abrahamsen, PR Ebeling
Summary: The risk of mortality associated with high dietary calcium is uncertain. Unlike a highly publicised study in Swedish wome..
N Mancuso, S Gayther, A Gusev, W Zheng, KL Penney, Z Kote-Jarai, R Eeles, M Freedman, C Haiman, B Pasaniuc, BE Henderson, S Benlloch, FR Schumacher, AAA Olama, K Muir, SI Berndt, DV Conti, F Wiklund, S Chanock, VL Stevens
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the..
MA Laaksonen, K Canfell, R Macinnis, ME Arriaga, E Banks, DJ Magliano, GG Giles, RG Cumming, JE Byles, P Mitchell, TK Gill, V Hirani, S McCullough, JE Shaw, AW Taylor, BA Adelstein, CM Vajdic
Background: Knowledge of preventable disease and differences in disease burden can inform public health action to improve health a..
O Stanesby, H Jayasekara, S Callinan, R Room, D English, GG Giles, RJ MacInnis, RL Milne, M Livingston
Background and Aims: In Australia, as in many countries, alcohol consumption increased dramatically during the second half of the ..
S Mahmood, DR English, RJ MacInnis, A Karahalios, N Owen, RL Milne, GG Giles, BM Lynch
2018-11-03
Background: Physical activity reduces the risk of colorectal cancer (CRC), but the relevant evidence derives primarily from self-r..
MJ Schoemaker, HB Nichols, LB Wright, MN Brook, ME Jones, KM O'Brien, HO Adami, L Baglietto, L Bernstein, KA Bertrand, MC Boutron-Ruault, T Braaten, Y Chen, AE Connor, M Dorronsoro, L Dossus, AH Eliassen, GG Giles, SE Hankinson, R Kaaks
2018-11-01
Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters..
MM Gaudet, GL Gierach, BD Carter, J Luo, RL Milne, E Weiderpass, GG Giles, RM Tamimi, AH Eliassen, B Rosner, A Wolk, HO Adami, KL Margolis, SM Gapstur, M Garcia-Closas, LA Brinton
2018-10-15
Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differ..
F Imamura, A Fretts, M Marklund, AV Ardisson Korat, WS Yang, M Lankinen, W Qureshi, C Helmer, TA Chen, K Wong, JK Bassett, R Murphy, N Tintle, CI Yu, IA Brouwer, KL Chien, AC Frazier-Wood, LC del Gobbo, L Djoussé, JM Geleijnse
2018-10-01
Background: We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 ..
Eline H van Roekel, Pierre-Antoine Dugue, Dallas R English, JiHoon E Joo, Ee Ming Wong, Enes Makalic, Melissa C Southey, Graham G Giles, Roger L Milne, Brigid M Lynch
Y Lu, A Beeghly-Fadiel, L Wu, X Guo, B Li, JM Schildkraut, HK Im, YA Chen, JB Permuth, BM Reid, JK Teer, KB Moysich, IL Andrulis, H Anton-Culver, BK Arun, EV Bandera, RB Barkardottir, DR Barnes, J Benitez, L Bjorge
2018-09-15
Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer..
PA Dugué, JG Dowty, JE Joo, EM Wong, E Makalic, DF Schmidt, DR English, JL Hopper, J Pedersen, G Severi, RJ MacInnis, RL Milne, GG Giles, MC Southey
Background: DNA methylation can mimic the effects of germline mutations in cancer predisposition genes. Recently, we identified tw..
E Gearon, A Peeters, W Ng, A Hodge, K Backholer
2018-09-01
Objectives: To quantify the mediating role of leisure time physical activity (LTPA) and five dietary behaviours on educational dif..
JA Chamberlain, PA Dugué, JK Bassett, AM Hodge, MT Brinkman, JHE Joo, CH Jung, E Makalic, DF Schmidt, JL Hopper, DD Buchanan, DR English, MC Southey, GG Giles, RL Milne
Background: Folate and other one-carbon metabolism nutrients are essential to enable DNA methylation to occur, but the extent to w..
PA Dugué, MT Brinkman, AM Hodge, JK Bassett, D Bolton, A Longano, JL Hopper, MC Southey, DR English, RL Milne, GG Giles
2018-07-15
Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mech..
SS Wang, M Carrington, SI Berndt, SL Slager, PM Bracci, J Voutsinas, JR Cerhan, KE Smedby, H Hjalgrim, J Vijai, LM Morton, R Vermeulen, O Paltiel, CM Vajdic, MS Linet, A Nieters, S de Sanjose, W Cozen, EE Brown, J Turner
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiolo..
FR Schumacher, AA Al Olama, SI Berndt, S Benlloch, M Ahmed, EJ Saunders, T Dadaev, D Leongamornlert, E Anokian, C Cieza-Borrella, C Goh, MN Brook, X Sheng, L Fachal, J Dennis, J Tyrer, K Muir, A Lophatananon, VL Stevens, SM Gapstur
2018-07-01
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susce..
SM Hussain, Y Wang, GG Giles, S Graves, AE Wluka, FM Cicuttini
Objective: To examine the associations of female reproductive and hormonal factors with incidence of total knee arthroplasty (TKA)..
M Seviiri, BM Lynch, AM Hodge, Y Yang, D Liew, DR English, GG Giles, RL Milne, PA Dugué
Objective Most studies investigating the association between resting heart rate (RHR) and mortality have focused on cardiovascular..
AM Hodge, JK Bassett, RL Milne, DR English, GG Giles
2018-06-01
Objective To test the hypothesis that more frequent consumption of sugar-sweetened soft drinks would be associated with increased ..
J Jeon, M Du, RE Schoen, M Hoffmeister, PA Newcomb, SI Berndt, B Caan, PT Campbell, AT Chan, J Chang-Claude, GG Giles, J Gong, TA Harrison, JR Huyghe, EJ Jacobs, L Li, Y Lin, L Le Marchand, JD Potter, C Qu
Background & Aims: Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lif..
S Li, EM Wong, PA Dugué, AF McRae, E Kim, JHE Joo, TL Nguyen, J Stone, GS Dite, NJ Armstrong, KA Mather, A Thalamuthu, MJ Wright, D Ames, RL Milne, JM Craig, R Saffery, GW Montgomery, YM Song, J Sung
Background: Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a globa..
LM Fitzgerald, S Zhao, A Leonardson, MS Geybels, S Kolb, DW Lin, JL Wright, R Eeles, Z Kote-Jarai, K Govindasami, GG Giles, MC Southey, J Schleutker, TL Tammela, C Sipeky, KL Penney, MJ Stampfer, H Gronberg, F Wiklund, P Stattin
Background: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several..
S Neumeyer, BL Banbury, V Arndt, SI Berndt, S Bezieau, SA Bien, DD Buchanan, K Butterbach, BJ Caan, PT Campbell, G Casey, AT Chan, SJ Chanock, JY Dai, S Gallinger, EL Giovannucci, GG Giles, WM Grady, J Hampe, M Hoffmeister
Background: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer..
AM Hodge, JK Bassett, PA Dugué, N Shivappa, JR Hébert, RL Milne, DR English, GG Giles
2018-05-01
Background and Aims: Dietary patterns are associated with risk of cardiovascular disease (CVD). We aimed to examine associations o..
PA Dugué, JK Bassett, JHE Joo, CH Jung, E Ming Wong, M Moreno-Betancur, D Schmidt, E Makalic, S Li, G Severi, AM Hodge, DD Buchanan, DR English, JL Hopper, MC Southey, GG Giles, RL Milne
2018-04-15
The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methy..
SC Dixon-Suen, CM Nagle, AP Thrift, PDP Pharoah, A Ewing, CL Pearce, W Zheng, G Chenevix-Trench, PA Fasching, MW Beckmann, D Lambrechts, I Vergote, S Lambrechts, E Van Nieuwenhuysen, MA Rossing, JA Doherty, KG Wicklund, J Chang-Claude, AY Jung, KB Moysich
2018-04-01
Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias..
S Hussain, Y Wang, GG Giles, S Graves, Anita Wluka, FM Cicuttini
A Rudolph, M Song, MN Brook, RL Milne, N Mavaddat, K Michailidou, MK Bolla, Q Wang, J Dennis, AN Wilcox, JL Hopper, MC Southey, R Keeman, PA Fasching, MW Beckmann, M Gago-Dominguez, JE Castelao, P Guénel, T Truong, SE Bojesen
Background: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially diff..
YM Geurts, PA Dugué, JE Joo, E Makalic, CH Jung, W Guan, S Nguyen, ML Grove, EM Wong, AM Hodge, JK Bassett, LM FitzGerald, H Tsimiklis, L Baglietto, G Severi, DF Schmidt, DD Buchanan, RJ MacInnis, JL Hopper, JS Pankow
Background/Objectives:There is increasing evidence of a relationship between blood DNA methylation and body mass index (BMI). We a..
LM Fitzgerald, CH Jung, EM Wong, JHE Joo, JA Gould, V Vasic, JK Bassett, N O'Callaghan, T Nottle, J Pedersen, GG Giles, MC Southey
Prognostic genomic biomarkers that can be measured at diagnosis to aid choice of treatment options are unavailable for most common..
M Barrdahl, F Canzian, MM Gaudet, SM Gapstur, A Trichopoulou, K Tsilidis, CH van Gils, S Borgquist, E Weiderpass, KT Khaw, GG Giles, RL Milne, L Le Marchand, C Haiman, S Lindström, P Kraft, DJ Hunter, R Ziegler, SJ Chanock, XR Yang
2018-03-15
We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of ..
PA Dugué, JK Bassett, JE Joo, L Baglietto, CH Jung, EM Wong, G Fiorito, D Schmidt, E Makalic, S Li, M Moreno-Betancur, DD Buchanan, P Vineis, DR English, JL Hopper, G Severi, MC Southey, GG Giles, RL Milne
2018-03-01
Measures of biological age based on blood DNA methylation, referred to as age acceleration (AA), have been developed. We examined ..
AL Van Dyke, MS Langhamer, B Zhu, RM Pfeiffer, D Albanes, G Andreotti, LEB Freeman, AT Chan, ND Freedman, SM Gapstur, GG Giles, F Grodstein, LM Liao, J Luo, RL Milne, KR Monroe, ML Neuhouser, JN Poynter, MP Purdue, K Robien
Background: Although some familial cancer syndromes include biliary tract cancers (BTCs; cancers of the gallbladder, intrahepatic ..
H Jayasekara, S Juneja, AM Hodge, R Room, RL Milne, JL Hopper, DR English, GG Giles, RJ MacInnis
Cohort studies have reported inconsistent evidence regarding alcohol intake and risk of non-Hodgkin lymphoma (NHL), mostly based o..
H Jayasekara, DR English, A Haydon, AM Hodge, BM Lynch, C Rosty, EJ Williamson, M Clendenning, MC Southey, MA Jenkins, R Room, JL Hopper, RL Milne, DD Buchanan, GG Giles, RJ MacInnis
2018-01-15
The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examin..
TE van Baak, C Coarfa, PA Dugué, G Fiorito, E Laritsky, MS Baker, NJ Kessler, J Dong, JD Duryea, MJ Silver, A Saffari, AM Prentice, SE Moore, A Ghantous, MN Routledge, YY Gong, Z Herceg, P Vineis, G Severi, JL Hopper
2018-01-09
Background: Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic vari..
K Krishnan, L Baglietto, J Stone, C McLean, MC Southey, DR English, GG Giles, JL Hopper
2017-12-16
Background: In a previous paper, we had assumed that the risk of screen-detected breast cancer mostly reflects inherent risk, and ..
J Malhotra, C Borron, ND Freedman, CC Abnet, PA Van Den Brandt, E White, RL Milne, GG Giles, P Boffetta
2017-12-01
Introduction: Use of non-cigarette tobacco products such as cigars and pipe has been increasing, even though these products entail..
RL Milne, AS Fletcher, RJ MacInnis, AM Hodge, AH Hopkins, JK Bassett, FJ Bruinsma, BM Lynch, PA Dugué, H Jayasekara, MT Brinkman, LV Popowski, L Baglietto, G Severi, K O'Dea, JL Hopper, MC Southey, DR English, GG Giles
X Shang, D Scott, A Hodge, DR English, GG Giles, PR Ebeling, KM Sanders
Background & aims: Limited data are available on the relationship of protein from different food sources with metabolic syndrome (..
G Fiorito, S Polidoro, PA Dugué, M Kivimaki, E Ponzi, G Matullo, S Guarrera, MB Assumma, P Georgiadis, SA Kyrtopoulos, V Krogh, D Palli, S Panico, C Sacerdote, R Tumino, M Chadeau-Hyam, S Stringhini, G Severi, AM Hodge, GG Giles
Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but..
O Brouckaert, A Rudolph, A Laenen, R Keeman, MK Bolla, Q Wang, A Soubry, H Wildiers, IL Andrulis, V Arndt, MW Beckmann, J Benitez, C Blomqvist, SE Bojesen, H Brauch, P Brennan, H Brenner, G Chenevix-Trench, JY Choi, S Cornelissen
2017-11-07
Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by su..
M Barrdahl, A Rudolph, JL Hopper, MC Southey, A Broeks, PA Fasching, MW Beckmann, M Gago-Dominguez, JE Castelao, P Guénel, T Truong, SE Bojesen, SM Gapstur, MM Gaudet, H Brenner, V Arndt, H Brauch, U Hamann, A Mannermaa, D Lambrechts
2017-11-01
Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene–environment..
F Gu, H Zhang, PL Hyland, S Berndt, SM Gapstur, W Wheeler, CI Amos, S Bezieau, H Bickeböller, H Brenner, P Brennan, J Chang-Claude, DV Conti, JA Doherty, SB Gruber, TA Harrison, RB Hayes, M Hoffmeister, RS Houlston, RJ Hung
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic varia..
MB McGuinness, RP Finger, A Karahalios, RH Guymer, DR English, EW Chong, AM Hodge, LD Robman, GG Giles, JA Simpson
2017-09-01
AimsTo assess associations between features of age-related macular degeneration (AMD) and mortality.MethodsA total of 21 129 parti..
HB Nichols, MJ Schoemaker, LB Wright, C McGowan, MN Brook, KM Mcclain, ME Jones, HO Adami, C Agnoli, L Baglietto, L Bernstein, KA Bertrand, WJ Blot, MC Boutron-Ruault, L Butler, Y Chen, MM Doody, L Dossus, AH Eliassen, GG Giles
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, inci..
MB McGuinness, A Karahalios, J Kasza, RH Guymer, RP Finger, JA Simpson
2017-07-04
Purpose: We illustrate the effect of survival bias when investigating risk factors for eye disease in elderly populations for whom..
SM Hussain, FM Cicuttini, GG Giles, SE Graves, AE Wluka, Y Wang
2017-07-01
Objective. The aim of this prospective cohort study was to determine whether dairy product consumption was associated with the inc..
AJ Rodríguez, D Scott, A Hodge, DR English, GG Giles, PR Ebeling
Summary: In older adults, lower bone density in the proximal femur was associated with increased heart burden, and this associatio..
Y Yang, BM Lynch, AM Hodge, D Liew, CA McLean, M Seviiri, MC Southey, JL Hopper, DR English, GG Giles, RL Milne, PA Dugué
Objective: Blood pressure (BP) and breast cancer may share a common pathophysiologic pathway involving chronic inflammation, hormo..
A Burton, G Maskarinec, B Perez-Gomez, C Vachon, H Miao, M Lajous, R López-Ridaura, M Rice, A Pereira, ML Garmendia, RM Tamimi, K Bertrand, A Kwong, G Ursin, E Lee, SA Qureshi, H Ma, S Vinnicombe, S Moss, S Allen
2017-06-01
Background: Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have bee..
MM Gaudet, BD Carter, LA Brinton, RT Falk, IT Gram, J Luo, RL Milne, SJ Nyante, E Weiderpass, LEB Freeman, DP Sandler, K Robien, KE Anderson, GG Giles, WY Chen, D Feskanich, T Braaten, C Isaacs, LM Butler, WP Koh
Background: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active c..
PT Campbell, CC Newton, CM Kitahara, AV Patel, P Hartge, J Koshiol, KA McGlynn, HO Adami, AB De Gonzalez, LEB Freeman, L Bernstein, JE Buring, ND Freedman, YT Gao, GG Giles, MJ Gunter, M Jenab, LM Liao, RL Milne, K Robien
2017-04-01
Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk ..
CD Warne, SG Zaloumis, NA Bertalli, MB Delatycki, AJ Nicoll, CE McLaren, JL Hopper, GG Giles, GJ Anderson, JK Olynyk, LW Powell, KJ Allen, LC Gurrin, M Bahlo, AR Fletcher, SM Forrest, NJ Osborne, CD Vulpe, L Turkovic
Background and Aim: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-rela..
H Jayasekara, RJ MacInnis, EJ Williamson, AM Hodge, M Clendenning, C Rosty, R Walters, R Room, MC Southey, MA Jenkins, RL Milne, JL Hopper, GG Giles, DD Buchanan, DR English
Ethanol in alcoholic beverages is a causative agent for colorectal cancer. Colorectal cancer is a biologically heterogeneous disea..
K Krishnan, L Baglietto, J Stone, JA Simpson, G Severi, CF Evans, RJ MacInnis, GG Giles, C Apicella, JL Hopper
Background: After adjusting for age and body mass index (BMI), mammographic measures-dense area (DA), percent dense area (PDA), an..
PJ Law, SI Berndt, HE Speedy, NJ Camp, GP Sava, CF Skibola, A Holroyd, V Joseph, NJ Sunter, A Nieters, S Bea, A Monnereau, D Martin-Garcia, LR Goldin, G Clot, LR Teras, I Quintela, BM Birmann, S Jayne, W Cozen
2017-02-06
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains un..
X Shang, D Scott, A Hodge, B Khan, N Khan, DR English, GG Giles, PR Ebeling, KM Sanders
2017-02-01
Objective: This study aimed to examine the association between baseline and changes in dietary quality assessed by the Alternative..
AE Taylor, RM Martin, MS Geybels, JL Stanford, I Shui, R Eeles, D Easton, Z Kote-Jarai, A Amin Al Olama, S Benlloch, K Muir, GG Giles, F Wiklund, H Gronberg, CA Haiman, J Schleutker, BG Nordestgaard, RC Travis, D Neal, N Pashayan
2017-01-15
Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if t..
K Backholer, Y Hirakawa, A Tonkin, G Giles, DJ Magliano, S Colagiuri, M Harris, P Mitchell, M Nelson, JE Shaw, D Simmons, L Simons, A Taylor, J Harding, B Gopinath, M Woodward
2017-01-06
Objective: To develop and recalibrate an Australian 5-year cardiovascular disease (CVD) mortality risk score to produce contempora..
L Baglietto, E Ponzi, P Haycock, A Hodge, M Bianca Assumma, CH Jung, J Chung, F Fasanelli, F Guida, G Campanella, M Chadeau-Hyam, K Grankvist, M Johansson, U Ala, P Provero, EM Wong, J Joo, DR English, N Kazmi, E Lund
2017-01-01
DNA methylation changes are associated with cigarette smoking. We used the Illumina Infinium HumanMethylation450 array to determin..
A Burton, G Byrnes, J Stone, RM Tamimi, J Heine, C Vachon, V Ozmen, A Pereira, ML Garmendia, C Scott, JH Hipwell, C Dickens, J Schüz, ME Aribal, K Bertrand, A Kwong, GG Giles, J Hopper, B Pérez Gómez, M Pollán
2016-12-19
Background: Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening ap..
RJ MacInnis, DF Schmidt, E Makalic, G Severi, LM FitzGerald, M Reumann, MK Kapuscinski, A Kowalczyk, Z Zhou, B Goudey, G Qian, QM Bui, DJ Park, A Freeman, MC Southey, AAA Olama, Z Kote-Jarai, RA Eeles, JL Hopper, GG Giles
2016-12-01
Background: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the numbe..
J Liu, I Loncar, JM Colleé, MK Bolla, J Dennis, K Michailidou, Q Wang, IL Andrulis, M Barile, MW Beckmann, S Behrens, J Benitez, C Blomqvist, B Boeckx, NV Bogdanova, SE Bojesen, H Brauch, P Brennan, H Brenner, A Broeks
2016-11-15
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a mi..
X Shang, D Scott, AM Hodge, DR English, GG Giles, PR Ebeling, KM Sanders
2016-11-01
Background: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent. ..
MB McGuinness, A Karahalios, JA Simpson, RH Guymer, LD Robman, AM Hodge, E Cerin, GG Giles, RP Finger
2016-10-01
Background/aims: To assess the association between past physical activity and early, intermediate and late age-related macular deg..
H Darabi, J Beesley, A Droit, S Kar, S Nord, MM Marjaneh, P Soucy, K Michailidou, M Ghoussaini, HF Wahl, MK Bolla, Q Wang, J Dennis, MR Alonso, IL Andrulis, H Anton-Culver, V Arndt, MW Beckmann, J Benitez, NV Bogdanova
2016-09-07
Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal va..
K Lawrenson, S Kar, K McCue, K Kuchenbaeker, K Michailidou, J Tyrer, J Beesley, SJ Ramus, Q Li, MK Delgado, JM Lee, K Aittomäki, IL Andrulis, H Anton-Culver, V Arndt, BK Arun, B Arver, EV Bandera, M Barile, RB Barkardottir
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46..
2016-09-01
To determine whether adiposity assessed by dual-energy X-ray absorptiometry (DXA) compared to simple anthropometric assessments, a..
A Wyszynski, CC Hong, K Lam, K Michailidou, C Lytle, S Yao, Y Zhang, MK Bolla, Q Wang, J Dennis, JL Hopper, MC Southey, MK Schmidt, A Broeks, K Muir, A Lophatananon, PA Fasching, MW Beckmann, J Peto, I dos Santos-Silva
Breast cancer is themost diagnosedmalignancy and the second leading cause of cancermortality in females. Previous association stud..
H Jayasekara, RJ MacInnis, AM Hodge, R Room, RL Milne, JL Hopper, GG Giles, DR English
Purpose: It is plausible that breast tissue is particularly susceptible to carcinogens, including ethanol, between menarche and th..
JK Bassett, DR English, MT Fahey, AB Forbes, LC Gurrin, JA Simpson, MT Brinkman, GG Giles, AM Hodge
Objective To evaluate the reliability and validity of the FFQ administered to participants in the follow-up of the Melbourne Colla..
SM Hussain, FM Cicuttini, GG Giles, SE Graves, Y Wang
2016-08-01
Objective Few studies have examined the association between circulating sex steroid concentrations and risk of osteoarthritis (OA)..
LC Del Gobbo, F Imamura, S Aslibekyan, M Marklund, JK Virtanen, M Wennberg, MY Yakoob, SE Chiuve, L Dela Cruz, AC Frazier-Wood, AM Fretts, E Guallar, C Matsumoto, K Prem, T Tanaka, JHY Wu, X Zhou, C Helmer, E Ingelsson, JM Yuan
Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversi..
PA Dugue, DR English, RJ MacInnis, CH Jung, JK Bassett, LM Fitzgerald, EM Wong, JE Joo, JL Hopper, MC Southey, GG Giles, RL Milne
2016-07-26
The reliability of methylation measures from the widely used HumanMethylation450 (HM450K) microarray has not been assessed for DNA..
AM Hodge, JK Bassett, N Shivappa, JR Hébert, DR English, GG Giles, G Severi
2016-07-01
Purpose: To investigate prospectively the associations of Dietary Inflammatory Index (DII) and Mediterranean Diet Score (MDS) with..
C Zeng, X Guo, J Long, KB Kuchenbaecker, A Droit, K Michailidou, M Ghoussaini, S Kar, A Freeman, JL Hopper, RL Milne, MK Bolla, Q Wang, J Dennis, S Agata, S Ahmed, K Aittomäki, IL Andrulis, H Anton-Culver, NN Antonenkova
2016-06-21
Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771..
K Krishnan, L Baglietto, C Apicella, J Stone, MC Southey, DR English, GG Giles, JL Hopper
2016-06-18
Background: Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent r..
SC Dixon, CM Nagle, AP Thrift, PDP Pharoah, CL Pearce, W Zheng, JN Painter, G Chenevix-Trench, PA Fasching, MW Beckmann, D Lambrechts, I Vergote, S Lambrechts, E Van Nieuwenhuysen, MA Rossing, JA Doherty, K GWicklund, J Chang-Claude, A Rudolph, KB Moysich
2016-06-01
Background: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. Howe..
M de la Hoya, O Soukarieh, I López-Perolio, A Vega, LC Walker, Y van Ierland, D Baralle, M Santamariña, V Lattimore, J Wijnen, P Whiley, A Blanco, M Raponi, J Hauke, B Wappenschmidt, A Becker, TVO Hansen, R Behar, null KConFaB Investigators, D Niederacher
A recent analysis using family history weighting and co-observation classification modeling indicated that BRCA1 c.594-2A>C (IVS9-..
JK Bassett, AM Hodge, DR English, RJ MacInnis, GG Giles
Purpose: This study prospectively investigates associations between fatty acids assessed in plasma phospholipids (PPL) and diet, a..
K Wu, D Spiegelman, T Hou, D Albanes, NE Allen, SI Berndt, PA Van Den Brandt, GG Giles, E Giovannucci, R Alexandra Goldbohm, GG Goodman, PJ Goodman, N Håkansson, M Inoue, TJ Key, LN Kolonel, S Männistö, ML McCullough, ML Neuhouser, Y Park
2016-05-15
Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate can..
Z Zhao, W Wen, K Michailidou, MK Bolla, Q Wang, B Zhang, J Long, XO Shu, MK Schmidt, RL Milne, M García-Closas, J Chang-Claude, S Lindstrom, SE Bojesen, H Ahsan, K Aittomäki, IL Andrulis, H Anton-Culver, V Arndt, MW Beckmann
2016-05-01
Purpose: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, ..
KS Purrington, DW Visscher, C Wang, D Yannoukakos, U Hamann, H Nevanlinna, A Cox, GG Giles, JE Eckel-Passow, S Lakis, V Kotoula, G Fountzilas, M Kabisch, T Rüdiger, P Heikkilä, C Blomqvist, SS Cross, MC Southey, JE Olson, J Gilbert
Distinct subtypes of triple negative (TN) breast cancer have been identified by tumor expression profiling. However, little is kno..
A Hollestelle, FH Van Der Baan, A Berchuck, SE Johnatty, KK Aben, BA Agnarsson, K Aittomäki, E Alducci, IL Andrulis, H Anton-Culver, NN Antonenkova, AC Antoniou, C Apicella, V Arndt, N Arnold, BK Arun, B Arver, A Ashworth, L Baglietto, R Balleine
Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microR..
RC Travis, PN Appleby, RM Martin, JMP Holly, D Albanes, A Black, HB Bueno-De-Mesquita, JM Chan, C Chen, MD Chirlaque, MB Cook, M Deschasaux, JL Donovan, L Ferrucci, P Galan, GG Giles, EL Giovannucci, MJ Gunter, LA Habel, FC Hamdy
2016-04-15
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the associati..
MJ Machiela, Q Lan, SL Slager, RCH Vermeulen, LR Teras, NJ Camp, JR Cerhan, JJ Spinelli, SS Wang, A Nieters, J Vijai, M Yeager, Z Wang, H Ghesquières, J McKay, L Conde, PIW de Bakker, DG Cox, L Burdett, A Monnereau
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with ..
A Gusev, H Shi, G Kichaev, M Pomerantz, F Li, HW Long, SA Ingles, RA Kittles, SS Strom, BA Rybicki, B Nemesure, WB Isaacs, W Zheng, CA Pettaway, ED Yeboah, Y Tettey, RB Biritwum, AA Adjei, E Tay, A Truelove
2016-04-07
Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer..
SI Berndt, NJ Camp, CF Skibola, J Vijai, Z Wang, J Gu, A Nieters, RS Kelly, KE Smedby, A Monnereau, W Cozen, A Cox, SS Wang, Q Lan, LR Teras, M Machado, M Yeager, AR Brooks-Wilson, P Hartge, MP Purdue
2016-03-09
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic sus..
RP Finger, E Chong, MB McGuinness, LD Robman, KZ Aung, G Giles, PN Baird, RH Guymer
2016-03-01
Purpose To determine the prevalence of reticular pseudodrusen (RPD) and its association with age-related macular degeneration (AMD..
DF Easton, F Lesueur, B Decker, K Michailidou, J Li, J Allen, C Luccarini, KA Pooley, M Shah, MK Bolla, Q Wang, J Dennis, J Ahmad, ER Thompson, F Damiola, M Pertesi, C Voegele, N Mebirouk, N Robinot, G Durand
2016-02-26
Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group fami..
A Karahalios, J Simpson, L Baglietto, RJ MacInnis, AM Hodge, GG Giles, DR English
2016-02-25
BACKGROUND: Studies reporting the association between change in weight or body mass index during midlife and risk of colorectal ca..
H Sung, M Garcia-Closas, J Chang-Claude, FM Blows, HR Ali, J Figueroa, H Nevanlinna, R Fagerholm, P Heikkilä, C Blomqvist, GG Giles, RL Milne, MC Southey, C McLean, A Mannermaa, VM Kosma, V Kataja, R Sironen, FJ Couch, JE Olson
2016-02-02
Background:Luminal A breast cancer defined as hormone receptor positive and human epidermal growth factor receptor 2 (HER2) negati..
CM Kitahara, ML McCullough, S Franceschi, S Rinaldi, A Wolk, G Neta, H Olov Adami, K Anderson, G Andreotti, LE Beane Freeman, L Bernstein, JE Buring, F Clavel-Chapelon, LA De Roo, YT Gao, JM Gaziano, GG Giles, N Håkansson, PL Horn-Ross, VA Kirsh
2016-02-01
Background: Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly p..
VA McCormack, A Burton, I dos-Santos-Silva, JH Hipwell, C Dickens, D Salem, R Kamal, M Hartman, CPL Lee, KS Chia, V Ozmen, ME Aribal, AA Flugelman, M Lajous, R Lopez-Riduara, M Rice, I Romieu, G Ursin, S Qureshi, H Ma
Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer ri..
Y Hamdi, P Soucy, V Adoue, K Michailidou, S Canisius, A Lemaçon, A Droit, IL Andrulis, H Anton-Culver, V Arndt, C Baynes, C Blomqvist, NV Bogdanova, SE Bojesen, MK Bolla, B Bonanni, AL Borresen-Dale, JS Brand, H Brauch, H Brenner
2016-01-01
There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-ac..
J Lei, A Rudolph, KB Moysich, S Behrens, EL Goode, MK Bolla, J Dennis, AM Dunning, DF Easton, Q Wang, J Benitez, JL Hopper, MC Southey, MK Schmidt, A Broeks, PA Fasching, L Haeberle, J Peto, I dos-Santos-Silva, EJ Sawyer
Immunosuppression plays a pivotal role in assisting tumors to evade immune destruction and promoting tumor development. We hypothe..
N Wong Doo, E Makalic, JE Joo, CM Vajdic, DF Schmidt, EM Wong, CH Jung, G Severi, DJ Park, J Chung, L Baglietto, HM Prince, JF Seymour, C Tam, JL Hopper, DR English, RL Milne, SJ Harrison, MC Southey, GG Giles
Aim: To examine whether peripheral blood methylation is associated with risk of developing mature B-cell neoplasms (MBCNs). Materi..
JB Permuth, B Reid, M Earp, YA Chen, ANA Monteiro, Z Chen, G Chenevix-Trench, PA Fasching, MW Beckmann, D Lambrechts, A Vanderstichele, E Van Niewenhuyse, I Vergote, MA Rossing, JA Doherty, J Chang-Claude, K Moysich, K Odunsi, MT Goodman, YB Shvetsov
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine ..
AJ Teichtahl, Y Wang, S Smith, AE Wluka, D Urquhart, GG Giles, SM Hussain, FM Cicuttini
2015-12-14
Introduction: Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. Thi..
H Jayasekara, RJ MacInnis, AM Hodge, JL Hopper, GG Giles, R Room, DR English
2015-12-01
© The Author 2014. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permission..
AJ Teichtahl, E Wulidasari, SRE Brady, Y Wang, AE Wluka, C Ding, GG Giles, FM Cicuttini
2015-11-10
Introduction: The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing..
TJ Key, PN Appleby, RC Travis, D Albanes, AJ Alberg, A Barricarte, A Black, H Boeing, HB Bueno-De-Mesquita, JM Chan, C Chen, MB Cook, JL Donovan, P Galan, R Gilbert, GG Giles, E Giovannucci, GE Goodman, PJ Goodman, MJ Gunter
2015-11-01
Background: Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostat..
JM Genkinger, CM Kitahara, L Bernstein, A Berrington de Gonzalez, M Brotzman, JW Elena, GG Giles, P Hartge, PN Singh, RZ Stolzenberg-Solomon, E Weiderpass, HO Adami, KE Anderson, LE Beane-Freeman, JE Buring, GE Fraser, CS Fuchs, SM Gapstur, JM Gaziano, KJ Helzlsouer
Background: Body mass index (BMI), a measure of obesity typically assessed in middle age or later, is known to be positively assoc..
X Guo, J Long, C Zeng, K Michailidou, M Ghoussaini, MK Bolla, Q Wang, RL Milne, XO Shu, Q Cai, J Beesley, SP Kar, IL Andrulis, H Anton-Culver, V Arndt, MW Beckmann, A Beeghly-Fadiel, J Benitez, W Blot, N Bogdanova
Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. I..
B Zhang, XO Shu, RJ Delahanty, C Zeng, K Michailidou, MK Bolla, Q Wang, J Dennis, W Wen, J Long, C Li, AM Dunning, J Chang-Claude, M Shah, BJ Perkins, K Czene, H Darabi, M Eriksson, SE Bojesen, BG Nordestgaard
Background: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the assoc..
B Khan, CA Nowson, RM Daly, DR English, AM Hodge, GG Giles, PR Ebeling
2015-10-01
The aim of this population-based, prospective cohort study was to investigate long-term associations between dietary calcium intak..
EW Chong, Y Wang, LD Robman, KZ Aung, GA Makeyeva, GG Giles, S Graves, FM Cicuttini, RH Guymer
2015-09-10
Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging..
AM Hodge, EJ Williamson, JK Bassett, RJ Macinnis, GG Giles, DR English
2015-09-01
The associations between intake of or circulating fatty acids and risk of colorectal cancer (CRC) are unclear. We examined prospec..
A Rudolph, PA Fasching, S Behrens, U Eilber, MK Bolla, Q Wang, D Thompson, K Czene, JS Brand, J Li, C Scott, VS Pankratz, K Brandt, E Hallberg, JE Olson, A Lee, MW Beckmann, AB Ekici, L Haeberle, G Maskarinec
2015-08-16
Introduction: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increase..
N Orr, F Dudbridge, N Dryden, S Maguire, D Novo, E Perrakis, N Johnson, M Ghoussaini, JL Hopper, MC Southey, C Apicella, J Stone, MK Schmidt, A Broeks, LJ Van't Veer, FB Hogervorst, PA Fasching, L Haeberle, AB Ekici, MW Beckmann
2015-05-15
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we ..
EW Chong, FM Amirul Islam, LD Robman, KZ Aung, AJ Richardson, PN Baird, RH Guymer
2015-05-08
Purpose: To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk varian..
Q Guo, MK Schmidt, P Kraft, S Canisius, C Chen, S Khan, J Tyrer, MK Bolla, Q Wang, J Dennis, K Michailidou, M Lush, S Kar, J Beesley, AM Dunning, M Shah, K Czene, H Darabi, M Eriksson, D Lambrechts
2015-05-01
Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be be..
N Mavaddat, PDP Pharoah, K Michailidou, J Tyrer, MN Brook, MK Bolla, Q Wang, J Dennis, AM Dunning, M Shah, R Luben, J Brown, SE Bojesen, BG Nordestgaard, SF Nielsen, H Flyger, K Czene, H Darabi, M Eriksson, J Peto
Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different level..
A Pirie, Q Guo, P Kraft, S Canisius, DM Eccles, N Rahman, H Nevanlinna, C Chen, S Khan, J Tyrer, MK Bolla, Q Wang, J Dennis, K Michailidou, M Lush, AM Dunning, M Shah, K Czene, H Darabi, M Eriksson
2015-04-22
© 2015 Pirie et al. Introduction: Previous studies have identified common germline variants nominally associated with breast cance..
LD Robman, FMA Islam, EWT Chong, MKM Adams, JA Simpson, KZ Aung, GA Makeyeva, JL Hopper, DR English, GG Giles, PN Baird, RH Guymer
2015-04-01
Purpose: To determine and compare the prevalence of age-related macular degeneration (AMD) in older Australians of Anglo-Celtic an..
SG Zaloumis, KJ Allen, NA Bertalli, L Turkovic, MB Delatycki, AJ Nicoll, CE Mclaren, DR English, JL Hopper, GG Giles, GJ Anderson, JK Olynyk, LW Powell, LC Gurrin, M Bahlo, CD Vulpe, SM Forrest, AR Fletcher
Background and Aim: The risk of hemochromatosis-related morbidity for HFE simple heterozygosity for either the C282Y or H63D subst..
A Rudolph, RL Milne, T Truong, JA Knight, P Seibold, D Flesch-Janys, S Behrens, U Eilber, MK Bolla, Q Wang, J Dennis, AM Dunning, M Shah, HR Munday, H Darabi, M Eriksson, JS Brand, J Olson, CM Vachon, E Hallberg
2015-03-15
A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between sing..
Yuanyuan Wang, Diaz Novera, Anita Wluka, Jessica Fairley, Graham G Giles, Richard O'Sullivan, Flavia M Cicuttini
2015-02-01
Y Wang, D Novera, AE Wluka, J Fairley, GG Giles, R O'Sullivan, FM Cicuttini
Objective. There is evidence of a vascular contribution to the pathogenesis of osteoarthritis (OA). The aim of this study was to e..
M Kabisch, JL Bermejo, T Dünnebier, S Ying, K Michailidou, MK Bolla, Q Wang, J Dennis, M Shah, BJ Perkins, K Czene, H Darabi, M Eriksson, SE Bojesen, BG Nordestgaard, SF Nielsen, H Flyger, D Lambrechts, P Neven, S Peeters
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variabil..
Purpose: Cohort studies have rarely examined the association between upper aero-digestive tract (UADT) cancer risk and lifetime al..
AJ Teichtahl, S Smith, Y Wang, AE Wluka, R O'Sullivan, GG Giles, FM Cicuttini
2015-01-28
Introduction: Occupational exposure to heavy lifting and stair climbing are associated with radiographic hip osteoarthritis (OA). ..
J Vijai, Z Wang, SI Berndt, CF Skibola, SL Slager, S De Sanjose, M Melbye, B Glimelius, PM Bracci, L Conde, BM Birmann, SS Wang, AR Brooks-Wilson, Q Lan, PIW De Bakker, RCH Vermeulen, C Portlock, SM Ansell, BK Link, J Riby
2015-01-08
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of ..
null Wei-Yu Lin, NJ Camp, M Ghoussaini, J Beesley, K Michailidou, JL Hopper, C Apicella, MC Southey, J Stone, MK Schmidt, A Broeks, LJ Van't Veer, EJ Th Rutgers, K Muir, A Lophatananon, S Stewart-Brown, P Siriwanarangsan, PA Fasching, L Haeberle, AB Ekici
2015-01-01
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the..
RL Milne, B Burwinkel, K Michailidou, JI Arias Perez, M Pilar Zamora, P Menéndez-Rodríguez, D Hardisson, M Mendiola, A González-Neira, G Pita, M Rosario Alonso, J Dennis, Q Wang, MK Bolla, A Swerdlow, A Ashworth, N Orr, M Schoemaker, YD Ko, H Brauch
2014-11-15
Candidate variant association studies havebeenlargely unsuccessful in identifyingcommonbreast cancer susceptibility variants, alth..
KS Purrington, S Slettedahl, MK Bolla, K Michailidou, K Czene, H Nevanlinna, SE Bojesen, IL Andrulis, A Cox, P Hall, J Carpenter, D Yannoukakos, C A. Haiman, PA Fasching, A Mannermaa, R Winqvist, H Brenner, A Lindblom, G Chenevix-Trench, J Benitez
Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candi..
S Khan, D Greco, K Michailidou, RL Milne, TA Muranen, T Heikkinen, K Aaltonen, J Dennis, MK Bolla, J Liu, P Hall, A Irwanto, K Humphreys, J Li, K Czene, J Chang-Claude, R Hein, A Rudolph, P Seibold, D Flesch-Janys
2014-11-12
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect t..
A Steffen, RJ MacInnis, G Joshy, GG Giles, E Banks, D Roder
2014-11-01
Background: Quantifying the risk of colorectal cancer for individuals is likely to be useful for health service provision. Our aim..
KA Phillips, FJ Bruinsma, RL Milne
2014-10-06
LE Kelemen, KL Terry, MT Goodman, PM Webb, EV Bandera, V McGuire, M Anne Rossing, Q Wang, E Dicks, JP Tyrer, H Song, J Kupryjanczyk, A Dansonka-Mieszkowska, J Plisiecka-Halasa, A Timorek, U Menon, A Gentry-Maharaj, SA Gayther, SJ Ramus, SA Narod
2014-10-01
Scope: We reevaluated previously reported associations between variants in pathways of onecarbon (1-C) (folate) transfer genes and..
C Rosty, EJ Williamson, M Clendenning, RJ Walters, AK Win, MA Jenkins, JL Hopper, IM Winship, MC Southey, GG Giles, DR English, DD Buchanan
Adenocarcinomas of the colon and rectum are graded using a 2-tiered system into histologic low-grade and high-grade tumors based o..
M Ghoussaini, SL Edwards, K Michailidou, S Nord, R Cowper-Sal-lari, K Desai, S Kar, KM Hillman, S Kaufmann, DM Glubb, J Beesley, J Dennis, MK Bolla, Q Wang, E Dicks, Q Guo, MK Schmidt, M Shah, R Luben, J Brown
2014-09-23
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 1..
J Fairley, J Toppi, FM Cicuttini, AE Wluka, GG Giles, J Cook, R O'Sullivan, Y Wang
2014-08-07
Background: Patellar tendinopathy is a common cause of activity-related anterior knee pain. Evidence is conflicting as to whether ..
A Karahalios, JA Simpson, L Baglietto, RJ MacInnis, AM Hodge, GG Giles, DR English
2014-07-02
Background: The association between change in weight or body mass index, and mortality is widely reported, however, both measures ..
J Li, LS Lindström, JN Foo, S Rafiq, MK Schmidt, PDP Pharoah, K Michailidou, J Dennis, MK Bolla, Q Wang, LJ Van'T Veer, S Cornelissen, E Rutgers, MC Southey, C Apicella, GS Dite, JL Hopper, PA Fasching, L Haeberle, AB Ekici
2014-06-17
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide po..
A Pettersson, RE Graff, G Ursin, I Dos Santos Silva, V McCormack, L Baglietto, C Vachon, MF Bakker, GG Giles, KS Chia, K Czene, L Eriksson, P Hall, M Hartman, RML Warren, G Hislop, AM Chiarelli, JL Hopper, K Krishnan, J Li
2014-05-14
Background Fibroglandular breast tissue appears dense on mammogram, whereas fat appears nondense. It is unclear whether absolute o..
RL Milne, J Herranz, K Michailidou, J Dennis, JP Tyrer, MP Zamora, JI Arias-Perez, A González-Neira, G Pita, MR Alonso, Q Wang, MK Bolla, K Czene, M Eriksson, K Humphreys, H Darabi, J Li, H Anton-Culver, SL Neuhausen, A Ziogas
2014-04-01
Part of the substantial unexplained familial aggregation of breast cancer may be due to interactions between common variants, but ..
D Agarwal, S Pineda, K Michailidou, J Herranz, G Pita, LT Moreno, MR Alonso, J Dennis, Q Wang, MK Bolla, KB Meyer, P Menéndez-Rodríguez, D Hardisson, M Mendiola, A González-Neira, A Lindblom, S Margolin, A Swerdlow, A Ashworth, N Orr
2014-02-18
Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as..
L Baglietto, K Krishnan, J Stone, C Apicella, MC Southey, DR English, JL Hopper, GG Giles
2014-02-15
Mammographic density measurements are associated with risk of breast cancer. Few studies have investigated the concurrent associat..
S Monira Hussain, Y Wang, FM Cicuttini, JA Simpson, GG Giles, S Graves, AE Wluka
2014-02-01
Objective: To examine whether components of metabolic syndrome (MetS), either singly or additively, were associated with the incid..
B Charbonneau, MS Block, WR Bamlet, RA Vierkant, KR Kalli, Z Fogarty, DN Rider, TA Sellers, SS Tworoger, E Poole, HA Risch, HB Salvesen, LA Kiemeney, L Baglietto, GG Giles, G Severi, B Trabert, N Wentzensen, G Chenevix-Trench, AS Whittemore
A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (r..
JR Cerhan, SC Moore, EJ Jacobs, CM Kitahara, PS Rosenberg, HO Adami, JO Ebbert, DR English, SM Gapstur, GG Giles, PL Horn-Ross, Y Park, AV Patel, K Robien, E Weiderpass, WC Willett, A Wolk, A Zeleniuch-Jacquotte, P Hartge, L Bernstein
2014-01-01
Objectives: To assess the independent effect of waist circumference on mortality across the entire body mass index (BMI) range and..
SM Hussain, Y Wang, DC Muller, AE Wluka, GG Giles, JT Manning, S Graves, FM Cicuttini
Objective: The data are conflicting for the association between the index-to-ring finger length ratio (2D:4D) and the risk of OA. ..
FM Amirul Islam, EW Chong, AM Hodge, RH Guymer, KZ Aung, GA Makeyeva, PN Baird, JL Hopper, DR English, GG Giles, LD Robman
Objective To evaluate the association between dietary patterns and age-related macular degeneration (AMD). Design Food frequency d..
E Sawyer, R Roylance, C Petridis, MN Brook, S Nowinski, E Papouli, O Fletcher, S Pinder, A Hanby, K Kohut, P Gorman, M Caneppele, J Peto, I dos Santos Silva, N Johnson, R Swann, M Dwek, KA Perkins, C Gillett, R Houlston
Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and ..
N Johnson, F Dudbridge, N Orr, L Gibson, ME Jones, MJ Schoemaker, EJ Folkerd, BP Haynes, JL Hopper, MC Southey, GS Dite, C Apicella, MK Schmidt, A Broeks, LJ Van't Veer, F Atsma, K Muir, A Lophatananon, PA Fasching, MW Beckmann
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22..
MA Earp, LE Kelemen, AM Magliocco, KD Swenerton, G Chenevix-Trench, Y Lu, A Hein, AB Ekici, MW Beckmann, PA Fasching, D Lambrechts, E Despierre, I Vergote, S Lambrechts, JA Doherty, MA Rossing, J Chang-Claude, A Rudolph, G Friel, KB Moysich
Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing t..
A Schoeps, A Rudolph, P Seibold, AM Dunning, RL Milne, SE Bojesen, A Swerdlow, I Andrulis, H Brenner, S Behrens, N Orr, M Jones, A Ashworth, J Li, H Cramp, D Connley, K Czene, H Darabi, SJ Chanock, J Lissowska
Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association ..
SM Hussain, FM Cicuttini, RJ Bell, PJ Robinson, SR Davis, GG Giles, S Graves, RL Milne, Y Wang
Objective The increased prevalence of osteoarthritis (OA) in postmenopausal women suggests that changes in either circulating sex ..
RJ Macinnis, AM Hodge, H Dixon, A Peeters, L Johnson, DR English, GG Giles
Objective To identify predictors of increased adiposity for different measures of adiposity. Design Prospective cohort study, the ..
H Marti-Soler, C Gubelmann, S Aeschbacher, L Alves, M Bobak, V Bongard, E Clays, G De Gaetano, A Di Castelnuovo, R Elosua, J Ferrieres, I Guessous, J Igland, T Jrøgensen, Y Nikitin, MG O'Doherty, L Palmieri, R Ramos, J Simons, G Sulo
Objective: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. Methods: Cr..
AJ Teichtahl, Y Wang, S Smith, AE Wluka, GG Giles, KL Bennell, R O'Sullivan, FM Cicuttini
INTRODUCTION: Few data are available concerning structural changes at the hip observed by magnetic resonance imaging (MRI) in peop..
A Rudolph, R Hein, S Lindström, L Beckmann, S Behrens, J Liu, H Aschard, MK Bolla, J Wang, T Truong, E Cordina-Duverger, F Menegaux, T Brüning, V Harth, WY Lo, G Severi, L Baglietto, M Southey, SJ Chanock, J Lissowska
2013-12-01
Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers o..
JK Bassett, G Severi, AM Hodge, RJ Macinnis, RA Gibson, JL Hopper, DR English, GG Giles
2013-10-15
Animal and experimental studies have demonstrated that long-chain n-3 fatty acids inhibit the development of prostate cancer, wher..
K Krishnan, JK Bassett, RJ MacInnis, DR English, JL Hopper, C McLean, GG Giles, L Baglietto
2013-08-01
Background: Adult weight is positively associated with postmenopausal breast cancer but few studies have investigated whether ther..
JK Bassett, L Baglietto, AM Hodge, G Severi, JL Hopper, DR English, GG Giles
Purpose: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-c..
AM Hodge, DR English, GG Giles, L Flicker
Objectives As populations age it is important to minimize the time people live in a less than successful state of ageing. Our aim ..
JK Bassett, G Severi, AM Hodge, L Baglietto, JL Hopper, DR English, GG Giles
2013-07-01
B vitamins are involved in 1-carbon metabolism, which is necessary for DNA replication, DNA repair, and regulation of gene express..
Y Wang, AE Wluka, JA Simpson, GG Giles, SE Graves, RN de Steiger, FM Cicuttini
2013-06-01
Objectives: To examine the relationships between weight at early and middle adulthood and adult weight gain and the risk of total ..
KZ Aung, G Makeyeva, MK Adams, EWT Chong, L Busija, GG Giles, DR English, J Hopper, PN Baird, RH Guymer, LD Robman
2013-05-01
PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this populatio..
O Obazee, C Justenhoven, S Winter, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, U Hannelius, J Li, K Humphreys, P Hall, G Giles, G Severi, L Baglietto, M Southey, S Rabstein, V Harth, A Lotz, B Pesch, T Brüning
2013-04-01
17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol. The current study ..
S Nickels, T Truong, R Hein, K Stevens, K Buck, S Behrens, U Eilber, M Schmidt, L Häberle, A Vrieling, M Gaudet, J Figueroa, N Schoof, AB Spurdle, A Rudolph, PA Fasching, JL Hopper, E Makalic, DF Schmidt, MC Southey
2013-03-27
Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with li..
JHE Joo, EM Wong, L Baglietto, CH Jung, H Tsimiklis, DJ Park, NC Wong, DR English, JL Hopper, G Severi, GG Giles, MC Southey
2013-03-15
Background: Dried blood (Guthrie card) spots provide an efficient way to collect and store blood specimens. DNA from this source h..
A Boillot, S Zoungas, P Mitchell, R Klein, B Klein, MK Ikram, C Klaver, JJ Wang, B Gopinath, ES Tai, AS Neubauer, S Hercberg, L Brazionis, SM Saw, TY Wong, S Czernichow
2013-02-06
Background: Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via ..
DC Muller, GG Giles, R Sinclair, JL Hopper, DR English, G Severi
2013-02-01
Background: Both prostate cancer and androgenetic alopecia are strongly age-related conditions that are considered to be androgen ..
MD Walsh, M Clendenning, E Williamson, SA Pearson, RJ Walters, B Nagler, D Packenas, AK Win, JL Hopper, MA Jenkins, AM Haydon, C Rosty, DR English, GG Giles, MA McGuckin, JP Young, DD Buchanan
2013-01-01
Mucinous differentiation is associated with both CpG island methylator phenotype and microsatellite instability in colorectal canc..
MM Gaudet, KB Kuchenbaecker, J Vijai, RJ Klein, T Kirchhoff, L McGuffog, D Barrowdale, AM Dunning, A Lee, J Dennis, S Healey, E Dicks, P Soucy, OM Sinilnikova, VS Pankratz, X Wang, RC Eldridge, DC Tessier, D Vincent, F Bacot
Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to dat..
A Hodge, OP Almeida, DR English, GG Giles, L Flicker
ABSTRACT Background: Anxiety and depression contribute to morbidity in elderly adults and may be associated with diet. We investig..
ML Davies-Tuck, R Kawasaki, AE Wluka, TY Wong, L Hodgson, DR English, GG Giles, F Cicuttini
2012-12-24
Background: Whether the increase in vascular disease prevalence and mortality in OA populations is a result of co-occurrence of ca..
A Siddiq, FJ Couch, GK Chen, S Lindström, D Eccles, RC Millikan, K Michailidou, DO Stram, L Beckmann, SK Rhie, CB Ambrosone, K Aittomäki, P Amiano, C Apicella, L Baglietto, EV Bandera, MW Beckmann, CD Berg, L Bernstein, C Blomqvist
2012-12-15
Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susc..
MKM Adams, JA Simpson, AJ Richardson, RH Guymer, E Williamson, S Cantsilieris, DR English, KZ Aung, GA Makeyeva, GG Giles, J Hopper, LD Robman, PN Baird
2012-12-01
Genetic variation in the gene encoding complement factor H (CFH) on chromosome 1q31 has repeatedly been associated with an increas..
DC Muller, L Baglietto, JT Manning, C McLean, JL Hopper, DR English, GG Giles, G Severi
2012-10-23
Background: We aimed to assess whether 2D: 4D measures are associated with breast cancer risk. Methods: We derived the ratio of th..
JK Bassett, G Severi, L Baglietto, RJ MacInnis, HN Hoang, JL Hopper, DR English, GG Giles
2012-10-01
The relationship between obesity and prostate cancer risk has been studied extensively but with inconsistent findings, particularl..
MKM Adams, EW Chong, E Williamson, KZ Aung, GA Makeyeva, GG Giles, DR English, J Hopper, RH Guymer, PN Baird, LD Robman, JA Simpson
2012-08-15
Little evidence exists regarding associations between age-related macular degeneration (AMD) and moderate alcohol consumption, pat..
R Hein, M Maranian, JL Hopper, MK Kapuscinski, MC Southey, DJ Park, MK Schmidt, A Broeks, FBL Hogervorst, HB Bueno-de-Mesquit, KR Muir, A Lophatananon, S Rattanamongkongul, P Puttawibul, PA Fasching, A Hein, AB Ekici, MW Beckmann, O Fletcher, N Johnson
2012-08-07
The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide ..
CM Kitahara, SS Wang, BS Melin, Z Wang, M Braganza, PD Inskip, D Albanes, U Andersson, LE Beane freeman, JE Buring, T Carreón, M Feychting, SM Gapstur, JM Gaziano, GG Giles, G Hallmans, SE Hankinson, R Henriksson, AW Hsing, C Johansen
2012-08-01
Background: Some, but not all, observational studies have suggested that taller stature is associated with a significant increased..
ML Davies-Tuck, Y Wang, AE Wluka, PA Berry, GG Giles, DR English, FM Cicuttini
Objective: There is evidence to suggest that elevated glucose concentration and clinical diabetes are associated with osteoarthrit..
D Lambrechts, T Truong, C Justenhoven, MK Humphreys, J Wang, JL Hopper, GS Dite, C Apicella, MC Southey, MK Schmidt, A Broeks, S Cornelissen, R van Hien, E Sawyer, I Tomlinson, M Kerin, N Miller, RL Milne, MP Zamora, JIA Pérez
2012-07-01
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, ..
JE Bailey-Wilson, EJ Childs, CD Cropp, DJ Schaid, J Xu, NJ Camp, LA Cannon-Albright, JM Farnham, A George, I Powell, JD Carpten, GG Giles, JL Hopper, G Severi, DR English, WD Foulkes, L Mæhle, P Møller, R Eeles, D Easton
2012-06-19
Background: Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiolo..
2012-06-01
Purpose: We investigated prospectively the relationship between dietary intakes of methionine, B vitamins associated with one-carb..
AJ Teichtahl, AE Wluka, Y Wang, A Forbes, ML Davies-Tuck, DR English, GG Giles, FM Cicuttini
Introduction: Whether participation in long-term vigorous physical activity affects knee cartilage is unclear and may depend on th..
Y Wang, LC Gurrin, AE Wluka, NA Bertalli, NJ Osborne, MB Delatycki, GG Giles, DR English, JL Hopper, JA Simpson, S Graves, KJ Allen, FM Cicuttini
Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoar..
L Yip, S Zaloumis, D Irwin, G Severi, J Hopper, G Giles, S Harrap, R Sinclair, J Ellis
2012-05-01
KK Tsilidis, RC Travis, PN Appleby, NE Allen, S Lindstrom, FR Schumacher, D Cox, AW Hsing, J Ma, G Severi, D Albanes, J Virtamo, H Boeing, HB Bueno-De-Mesquita, M Johansson, JR Quirós, E Riboli, A Siddiq, A Tjønneland, D Trichopoulos
Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) associated with prostate cancer..
MKM Adams, JA Simpson, AJ Richardson, DR English, KZ Aung, GA Makeyeva, RH Guymer, GG Giles, J Hopper, LD Robman, PN Baird
2012-03-15
The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported association..
AJ Teichtahl, F Hanna, AE Wluka, DM Urquhart, Y Wang, DR English, GG Giles, FM Cicuttini
2012-03-01
PURPOSE: The bony articular surface contributes to a joint's congruency, and it might be a determinant of structural change. The a..
L Lu, G Cancel-Tassin, A Valeri, O Cussenot, EM Lange, KA Cooney, JM Farnham, NJ Camp, LA Cannon-Albright, TLJ Tammela, J Schleutker, J Hoegel, K Herkommer, C Maier, W Vogel, F Wiklund, M Emanuelsson, H Grönberg, KE Wiley, SD Isaacs
BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely in..
JK Bassett, AM Hodge, DR English, L Baglietto, JL Hopper, GG Giles, G Severi
2012-02-01
Background/Objectives:B vitamins and related enzymes involved in one-carbon metabolism are necessary for DNA replication, DNA repa..
H Warren, F Dudbridge, O Fletcher, N Orr, N Johnson, JL Hopper, C Apicella, MC Southey, M Mahmoodi, MK Schmidt, A Broeks, S Cornelissen, LM Braaf, KR Muir, A Lophatananon, A Chaiwerawattana, S Wiangnon, PA Fasching, MW Beckmann, AB Ekici
2012-01-01
Background: Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686). M..
C Justenhoven, O Obazee, S Winter, FJ Couch, JE Olson, P Hall, U Hannelius, J Li, K Humphreys, G Severi, G Giles, M Southey, L Baglietto, PA Fasching, MW Beckmann, AB Ekici, U Hamann, C Baisch, V Harth, S Rabstein
KN Stevens, M Garcia-Closas, Z Fredericksen, M Kosel, VS Pankratz, JL Hopper, GS Dite, C Apicella, MC Southey, MK Schmidt, A Broeks, LJ Van T Veer, RAEM Tollenaar, PA Fasching, MW Beckmann, A Hein, AB Ekici, N Johnson, J Peto, I Dos Santos Silva
2011-12-06
Background: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and hav..
JD Figueroa, M Garcia-Closas, M Humphreys, R Platte, JL Hopper, MC Southey, C Apicella, F Hammet, MK Schmidt, A Broeks, RAEM Tollenaar, LJ Van't Veer, PA Fasching, MW Beckmann, AB Ekici, R Strick, J Peto, IDS Silva, O Fletcher, N Johnson
2011-12-01
A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast..
LR Harriss, AE Ajani, D Hunt, J Shaw, B Chambers, H Dewey, J Frayne, A Beauchamp, K Duvé, GG Giles, S Harrap, DJ Magliano, D Liew, J McNeil, A Peeters, M Stebbing, R Wolfe, A Tonkin
2011-10-01
Objective: This study investigated the sensitivity and specificity of the national mortality codes in identifying cardiovascular d..
KN Stevens, CM Vachon, AM Lee, S Slager, T Lesnick, C Olswold, PA Fasching, P Miron, D Eccles, JE Carpenter, AK Godwin, C Ambrosone, R Winqvist, H Brauch, MK Schmidt, A Cox, SS Cross, E Sawyer, A Hartmann, MW Beckmann
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about..
FR Schumacher, SI Berndt, A Siddiq, KB Jacobs, Z Wang, S Lindstrom, VL Stevens, C Chen, AM Mondul, RC Travis, DO Stram, RA Eeles, DF Easton, G Giles, JL Hopper, DE Neal, FC Hamdy, JL Donovan, K Muir, AA Al Olama
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading caus..
P Peterlongo, L Caleca, E Cattaneo, F Ravagnani, T Bianchi, L Galastri, L Bernard, F Ficarazzi, V Dall'olio, F Marme, A Langheinz, C Sohn, B Burwinkel, GG Giles, L Baglietto, G Severi, FA Odefrey, MC Southey, A Osorio, F Fernández
AM Hodge, DR English, C Itsiopoulos, K O'Dea, GG Giles
2011-09-01
Background and aims: Diabetes is a risk factor for cardiovascular disease (CVD), yet southern European migrants to Australia with ..
A Broeks, MK Schmidt, ME Sherman, FJ Couch, JL Hopper, GS Dite, C Apicella, LD Smith, F Hammet, MC Southey, LJ Van't Veer, R De Groot, VTHBM Smit, PA Fasching, MW Beckmann, S Jud, AB Ekici, A Hartmann, A Hein, R Schulz-Wendtland
2011-08-15
Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk asso..
AM Hodge, AJ Jenkins, DR English, K O'Dea, GG Giles
2011-08-01
Background and aims: Dyslipidemia is influenced by diet and body habitus. The Nuclear Magnetic Resonance spectroscopy lipoprotein ..
DC Muller, GG Giles, JT Manning, JL Hopper, DR English, G Severi
2011-07-26
Background: The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low ..
MKM Adams, JA Simpson, KZ Aung, GA Makeyeva, GG Giles, DR English, J Hopper, RH Guymer, PN Baird, LD Robman
2011-06-01
Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined assoc..
DC Muller, GG Giles, J Bassett, HA Morris, JT Manning, JL Hopper, DR English, G Severi
2011-04-27
Background: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this s..
NA Bertalli, KJ Allen, CE Mclaren, L Turkovic, NJ Osborne, CC Constantine, MB Delatycki, DR English, GG Giles, JL Hopper, GJ Anderson, JK Olynyk, LW Powell, LC Gurrin
2011-04-19
BACKGROUND: Questionnaire-based studies investigating blood donation history rely on the accurate recall of information from parti..
L Baglietto, GG Giles, DR English, A Karahalios, JL Hopper, G Severi
2011-04-15
Despite the brain being highly susceptible to the action of alcohol and, therefore, potentially susceptible to its carcinogenic ef..
A Beauchamp, AM Tonkin, H Kelsall, V Sundararajan, DR English, L Sundaresan, R Wolfe, G Turrell, GG Giles, A Peeters
2011-04-11
Background: Cohort studies can provide valuable evidence of cause and effect relationships but are subject to loss of participants..
AMG Ali, SJ Dawson, FM Blows, E Provenzano, IO Ellis, L Baglietto, D Huntsman, C Caldas, PD Pharoah
2011-02-15
Background:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epi..
XR Yang, J Chang-Claude, EL Goode, FJ Couch, H Nevanlinna, RL Milne, M Gaudet, MK Schmidt, A Broeks, A Cox, PA Fasching, R Hein, AB Spurdle, F Blows, K Driver, D Flesch-Janys, J Heinz, P Sinn, A Vrieling, T Heikkinen
2011-02-02
Background Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progeste..
L Baglietto, K Krishnan, G Severi, A Hodge, M Brinkman, DR English, C McLean, JL Hopper, GG Giles
2011-02-01
Background: Evidence is emerging that prudent/healthy dietary patterns might be associated with a reduced risk of breast cancer. M..
Y Wang, JA Simpson, AE Wluka, AJ Teichtahl, DR English, GG Giles, S Graves, FM Cicuttini
Objective. To estimate prospectively any association between measures of physical activity and the risk of either primary knee or ..
Y Wang, JA Simpson, AE Wluka, DR English, GG Giles, S Graves, FM Cicuttini
2011-01-18
Background: There is emerging evidence for a beneficial effect of meat consumption on the musculoskeletal system. However, whether..
RL Milne, EL Goode, M García-Closas, FJ Couch, G Severi, R Hein, Z Fredericksen, N Malats, MP Zamora, JIA Pérez, J Benítez, T Dörk, P Schürmann, JH Karstens, P Hillemanns, A Cox, IW Brock, G Elliot, SS Cross, S Seal
2011-01-01
Background: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, p..
RL Milne, MM Gaudet, AB Spurdle, PA Fasching, FJ Couch, J Benítez, JI Arias Pérez, MP Zamora, N Malats, I dos Santos Silva, LJ Gibson, O Fletcher, N Johnson, H Anton-Culver, A Ziogas, J Figueroa, L Brinton, ME Sherman, J Lissowska, JL Hopper
2010-12-31
Introduction: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine ho..
F Chionh, L Baglietto, K Krishnan, DR English, RJ MacInnis, DM Gertig, JL Hopper, GG Giles
2010-12-01
Objectives: We examined the association between risk of ovarian cancer and physical activity and anthropometry (body mass index, h..
A Beauchamp, A Tonkin, A Peeters, R Wolfe, G Turrell, L Harriss, GG Giles, DR English, AJ Jenkins
2010-11-01
Background: The relationship between cigarette smoking and cardiovascular disease is well established, yet the underlying mechanis..
JK Bassett, G Severi, DR English, L Baglietto, K Krishnan, JL Hopper, GG Giles
Background: Epidemiologic studies have consistently reported positive associations between obesity and colon cancer risk for men, ..
G Severi, L Baglietto, DC Muller, DR English, MA Jenkins, MJ Abramson, JA Douglass, JL Hopper, GG Giles
2010-09-01
Background: The aim of this study was to assess whether a history of asthma or the use of asthma medications is associated with pr..
KJ Allen, NA Bertalli, NJ Osborne, CC Constantine, MB Delatycki, AE Nisselle, AJ Nicoll, DM Gertig, CE McLaren, GG Giles, JL Hopper, GJ Anderson, JK Olynyk, LW Powell, LC Gurrin
Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is a genetic predisposition to iron overload and subsequent ..
O Fletcher, N Johnson, I Dos Santos Silva, A Ashworth, H Nevanlinna, T Heikkinen, K Aittomäki, C Blomqvist, B Burwinkel, CR Bartram, A Meindl, RK Schmutzler, A Cox, I Brock, G Elliott, MWR Reed, MC Southey, L Smith, AB Spurdle, JL Hopper
Background: Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants ..
GB Christensen, AB Baffoe-Bonnie, A George, I Powell, JE Bailey-Wilson, JD Carpten, GG Giles, JL Hopper, G Severi, DR English, WD Foulkes, L Maehle, P Moller, R Eeles, D Easton, MD Badzioch, AS Whittemore, I Oakley-Girvan, CL Hsieh, L Dimitrov
2010-05-15
BACKGROUND. Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility gen..
EM Azzato, J Tyrer, PA Fasching, MW Beckmann, AB Ekici, R Schulz-Wendtland, SE Bojesen, BG Nordestgaard, H Flyger, RL Milne, JI Arias, P Menéndez, J Benítez, J Chang-Claude, R Hein, S Wang-Gohrke, H Nevanlinna, T Heikkinen, K Aittomäki, C Blomqvist
2010-05-01
Background Traditional prognostic factors for survival and treatment response of patients with breast cancer do not fully account ..
FM Blows, KE Driver, MK Schmidt, A Broeks, FE van Leeuwen, J Wesseling, MC Cheang, K Gelmon, TO Nielsen, C Blomqvist, P Heikkila, T Heikkinen, H Nevanlinna, LA Akslen, LR Bégin, WD Foulkes, FJ Couch, X Wang, V Cafourek, JE Olson
Background: Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and ..
MKM Adams, LD Robman, JA Simpson, KZ Aung, GA Makeyeva, GG Giles, DR English, RH Guymer, PN Baird
2010-04-01
NJ Osborne, LC Gurrin, KJ Allen, CC Constantine, MB Delatycki, CE McLaren, DM Gertig, GJ Anderson, MC Southey, JK Olynyk, LW Powell, JL Hopper, GG Giles, DR English
The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Mel..
LD Robman, MK Adams, JA Simpson, KZ Aung, GA Makeyeva, GG Giles, DR English, PN Baird, RH Guymer
KZ Aung, SS Wickremasinghe, G Makeyeva, L Robman, RH Guymer
2010-03-01
Purpose: The purpose of this study was to determine the prevalence estimates of macular telangiectasia type 2 in an Australian pop..
L Baglietto, G Severi, DR English, K Krishnan, JL Hopper, C McLean, HA Morris, WD Tilley, GG Giles
2010-02-01
Epidemiologic studies have consistently reported that endogenous steroid hormone levels are associated with postmenopausal breast ..
MT Brinkman, L Baglietto, K Krishnan, DR English, G Severi, HA Morris, JL Hopper, GG Giles
Background/Objectives: Little is known about nutritional factors that influence circulating concentrations of steroid hormones, wh..
ML Davies-Tuck, AE Wluka, A Forbes, Y Wang, DR English, GG Giles, R O'Sullivan, FM Cicuttini
2010-01-19
Introduction: To examine the relationship between development or resolution of bone marrow lesions (BMLs) and knee cartilage prope..
SJ Dawson, N Makretsov, FM Blows, KE Driver, E Provenzano, J Le Quesne, L Baglietto, G Severi, GG Giles, CA McLean, G Callagy, AR Green, I Ellis, K Gelmon, G Turashvili, S Leung, S Aparicio, D Huntsman, C Caldas, P Pharoah
2010-01-01
Background: Breast cancer is heterogeneous and the existing prognostic classifiers are limited in accuracy, leading to unnecessary..
A Beauchamp, A Peeters, R Wolfe, G Turrell, LR Harriss, GG Giles, DR English, J McNeil, D Magliano, S Harrap, D Liew, D Hunt, A Tonkin
While the relationship between socio-economic disadvantage and cardiovascular disease (CVD) is well established, the role that tra..
AM Hodge, JA Simpson, M Fridman, K Rowley, DR English, GG Giles, Q Su, K Odea
2009-12-01
Objective: To evaluate FFQ estimates of dietary intake of individual antioxidants, fruit and vegetables in comparison to plasma co..
Background Female pattern hair loss (FPHL) is a common trait in which androgens and oestrogens may have a pathogenic role. The aro..
LC Gurrin, NA Bertalli, GW Dalton, NJ Osborne, CC Constantine, CE McLaren, DR English, DM Gertig, MB Delatycki, AJ Nicoll, MC Southey, JL Hopper, GG Giles, GJ Anderson, JK Olynyk, LW Powell, KJ Allen
2009-11-25
The risk of hemochromatosis-related morbidity is unknown among HFE compound heterozygotes (C282Y/H63D). We used a prospective popu..
M Guy, Z Kote-Jarai, GG Giles, AA Al Olama, SK Jugurnauth, S Mulholland, DA Leongamornlert, SM Edwards, J Morrison, HI Field, MC Southey, G Severi, JL Donovan, FC Hamdy, DP Dearnaley, KR Muir, C Smith, M Bagnato, AT Ardern-Jones, AL Hall
2009-09-21
There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes ..
CES Comstock, MA Augello, R Pe Benito, J Karch, TH Tran, FE Utama, EA Tindall, Y Wang, CJ Burd, EM Groh, HN Hoang, GG Giles, G Severi, VM Hayes, BE Henderson, L Le Marchand, LN Kolonel, CA Haiman, R Baffa, LG Gomella
2009-09-01
Purpose: Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared ..
AJ Teichtahl, AE Wluka, A Forbes, Y Wang, DR English, GG Giles, FM Cicuttini
2009-08-15
Objective. There are few data concerning possible long-term effects of physical activity on cartilage change in the patellofemoral..
KZ Aung, L Robman, DR English, GG Giles, RH Guymer
2009-07-22
Purpose: In an elderly Australian population, to evaluate the quality of fundus photographs taken non-mydriatically in both eyes, ..
RL Milne, J Benítez, H Nevanlinna, T Heikkinen, K Aittomäki, C Blomqvist, JI Arias, MP Zamora, B Burwinkel, CR Bartram, A Meindl, RK Schmutzler, A Cox, I Brock, G Elliott, MWR Reed, MC Southey, L Smith, AB Spurdle, JL Hopper
2009-07-01
BackgroundA recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of su..
Y Wang, JA Simpson, AE Wluka, DM Urquhart, DR English, GG Giles, S Graves, FM Cicuttini
2009-06-08
Introduction: Racial and ethnic disparities in rates of total joint replacement have been described, but little work has been done..
AJ Teichtahl, AE Wluka, Y Wang, F Hanna, DR English, GG Giles, FM Cicuttini
2009-06-01
Objectives: The aim of this study was to determine whether measures of obesity and adiposity are associated with the rate of patel..
ML Davies-Tuck, AE Wluka, Y Wang, DR English, GG Giles, F Cicuttini
Objective: Although bone marrow lesions (BML) have been implicated in the pathogenesis of osteoarthritis, their natural history in..
Y Wang, ML Davies-Tuck, AE Wluka, A Forbes, DR English, GG Giles, R O'Sullivan, FM Cicuttini
2009-05-08
Introduction: Fatty acids have been implicated in osteoarthritis (OA), yet the mechanism by which fatty acids affect knee structur..
L Baglietto, DR English, JL Hopper, RJ MacInnis, HA Morris, WD Tilley, K Krishnan, GG Giles
2009-05-01
Steroid hormones are associated with the risk of postmenopausal breast cancer and evidence suggests that increased concentrations ..
EWT Chong, LD Robman, JA Simpson, AM Hodge, KZ Aung, TK Dolphin, DR English, GG Giles, RH Guymer
Objective: To evaluate associations between past dietary fat intake and the prevalence of age-related macular degeneration (AMD). ..
MM Gaudet, RL Milne, A Cox, NJ Camp, EL Goode, MK Humphreys, AM Dunning, J Morrison, GG Giles, G Severi, L Baglietto, DR English, FJ Couch, JE Olson, X Wang, J Chang-Claude, D Flesch-Janys, S Abbas, R Salazar, A Mannermaa
Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8..
S Ahmed, G Thomas, M Ghoussaini, CS Healey, MK Humphreys, R Platte, J Morrison, M Maranian, KA Pooley, R Luben, D Eccles, DG Evans, O Fletcher, N Johnson, I Dos Santos Silva, J Peto, MR Stratton, N Rahman, K Jacobs, R Prentice
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fra..
EWT Chong, JA Simpson, LD Robman, AM Hodge, KZ Aung, DR English, GG Giles, RH Guymer
2009-04-01
Age-related macular degeneration (AMD) is the leading cause of blindness among older people, and diet has been postulated to alter..
AM Dunning, CS Healey, C Baynes, AT Maia, S Scollen, A Vega, R Rodríguez, NL Barbosa-Morais, BAJ Ponder, YL Low, S Bingham, CA Haiman, L Le Marchand, A Broeks, MK Schmidt, J Hopper, M Southey, MW Beckmann, PA Fasching, J Peto
2009-03-13
We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variant..
2009-03-05
Introduction: Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. It is unknown wh..
ML Davies-Tuck, AE Wluka, A Forbes, Y Wang, DR English, GG Giles, F Cicuttini
2009-01-01
OBJECTIVE: To determine whether smoking is related to change in tibial and patella cartilage, and the development or persistence o..
HL Kelsall, L Baglietto, D Muller, AM Haydon, DR English, GG Giles
Previous research relating lower socioeconomic status (SES) with poorer survival from colorectal cancer has varied in adjustment f..
PA Berry, AJ Teichtahl, A Galevska-Dimitrovska, FS Hanna, AE Wluka, Y Wang, DM Urquhart, DR English, GG Giles, FM Cicuttini
2008-12-15
Introduction: Although vastus medialis and lateralis are important determinants of patellofemoral joint function, their relationsh..
AM Pittman, E Webb, L Carvajal-Carmona, K Howarth, MC Di Bernardo, P Broderick, S Spain, A Walther, A Price, K Sullivan, P Twiss, S Fielding, A Rowan, E Jaeger, J Vijayakrishnan, I Chandler, S Penegar, M Qureshi, S Lubbe, E Domingo
2008-11-19
The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colo..
H Mitchell, DR English, F Elliott, M Gengos, JH Barrett, GG Giles, D Forman
2008-10-01
Background: Enzyme-linked immunosorbent assays (ELISAs) for detection of Helicobacter pylori infection, using IgG antibodies, may ..
AE Wluka, Y Wang, M Davies-Tuck, DR English, GG Giles, FM Cicuttini
2008-09-08
Objective. In knee OA, the presence of bone marrow lesions (BMLs) predicts pain and progression of disease. Their occurrence has b..
R Eeles, G Giles, D Neal, K Muir, DF Easton
2008-09-01
Z Kote-Jarai, DF Easton, JL Stanford, EA Ostrander, J Schleutker, SA Ingles, D Schaid, S Thibodeau, T Dörk, D Neal, A Cox, C Maier, W Vogel, M Guy, K Muir, A Lophatananon, MA Kedda, A Spurdle, S Steginga, EM John
2008-08-01
A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with p..
M Ghoussaini, H Song, T Koessler, AA Al Olama, Z Kote-Jarai, KE Driver, KA Pooley, SJ Ramus, SK Kjaer, E Hogdall, RA DiCioccio, AS Whittemore, SA Gayther, GG Giles, M Guy, SM Edwards, J Morrison, JL Donovan, FC Hamdy, DP Dearnaley
2008-07-01
Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various geneti..
IPM Tomlinson, E Webb, L Carvajal-Carmona, P Broderick, K Howarth, AM Pittman, S Spain, S Lubbe, A Walther, K Sullivan, E Jaeger, S Fielding, A Rowan, J Vijayakrishnan, E Domingo, I Chandler, Z Kemp, M Qureshi, SM Farrington, A Tenesa
2008-05-01
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped..
Y Wang, AE Wluka, AM Hodge, DR English, GG Giles, R O'Sullivan, FM Cicuttini
Objective: There is evidence that omega-3 polyunsaturated fatty acids alleviate the progression of osteoarthritis (OA). However, l..
RA Eeles, Z Kote-Jarai, GG Giles, AAA Olama, M Guy, SK Jugurnauth, S Mulholland, DA Leongamornlert, SM Edwards, J Morrison, HI Field, MC Southey, G Severi, JL Donovan, FC Hamdy, DP Dearnaley, KR Muir, C Smith, M Bagnato, AT Ardern-Jones
2008-03-01
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggrega..
AJ Teichtahl, Y Wang, AE Wluka, M Szramka, DR English, GG Giles, R O'Sullivan, FM Cicuttini
2008-02-01
Background:Although obesity is a risk factor for patellofemoral osteoarthritis (OA), it is unclear whether the components of body ..
KJ Allen, LC Gurrin, CC Constantine, NJ Osborne, MB Delatycki, AJ Nicoll, CE McLaren, M Bahlo, AE Nisselle, CD Vulpe, GJ Anderson, MC Southey, GG Giles, DR English, JL Hopper, JK Olynyk, LW Powell, DM Gertig
2008-01-17
Background: Most persons who are homozygous for C282Y, the HFE allele most commonly asssociated with hereditary hemochromatosis, h..
LC Gurrin, NJ Osborne, CC Constantine, CE McLaren, DR English, DM Gertig, MB Delatycki, MC Southey, JL Hopper, GG Giles, GJ Anderson, JK Olynyk, LW Powell, KJ Allen
2008-01-01
Background & Aims: There are few longitudinal studies of serum ferritin (SF) and transferrin saturation (TS) levels in individuals..
TL Racunica, AJ Teichtahl, Y Wang, AE Wluka, DR English, GG Giles, R O'Sullivan, FM Cicuttini
2007-10-15
Objective. It is unclear whether physical activity that is beneficial for the cardiovascular system is detrimental to knee structu..
LR Harriss, DR English, JL Hopper, J Powles, JA Simpson, K O'Dea, GG Giles, AM Tonkin
2007-10-01
Aims: To investigate the relationship between usual daily alcohol intake, beverage type and drinking frequency on cardiovascular (..
Y Wang, AM Hodge, AE Wluka, DR English, GG Giles, R O'Sullivan, A Forbes, FM Cicuttini
2007-07-06
The aim of the present study is to examine the effect of dietary antioxidants on knee structure in a cohort of healthy, middle-age..
AM Hodge, JA Simpson, RA Gibson, AJ Sinclair, M Makrides, K O'Dea, DR English, GG Giles
2007-07-01
Background and aim: As an evaluation of fatty acid intake measurement, our aim was to examine associations between diet and plasma..
NJ Camp, LA Cannon-Albright, JM Farnham, AB Baffoe-Bonnie, A George, I Powell, JE Bailey-Wilson, JD Carpten, GG Giles, JL Hopper, G Severi, DR English, WD Foulkes, L Maehle, P Moller, R Eeles, D Easton, MD Badzioch, AS Whittemore, I Oakley-Girvan
2007-06-01
Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12..
TL Racunica, M Szramka, AE Wluka, Y Wang, DR English, GG Giles, R O'Sullivan, FM Cicuttini
2007-05-01
Objective: To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with ..
JA Simpson, RJ MacInnis, A Peeters, JL Hopper, GG Giles, DR English
2007-04-01
Objective: Our goal was to examine five different measures of adiposity as predictors of all-cause mortality. Research Methods and..
AM Hodge, DR English, K O'Dea, GG Giles
2007-03-01
The authors investigated the association of dietary patterns and type 2 diabetes in a 4-year prospective study of 36,787 adults in..
E Milne, JA Simpson, R Johnston, B Giles-Corti, DR English
2007-02-01
Objectives. We investigated whether the Kidskin sun protection intervention increased children's body mass index by reducing the t..
RJ MacInnis, DR English, AM Haydon, JL Hopper, DM Gertig, GG Giles
2006-12-01
Background: Although body mass index has been shown to be associated with colon cancer, studies of rectal cancer risk have general..
L Baglietto, DR English, JL Hopper, J Powles, GG Giles
2006-11-01
Background: The objective was to investigate associations between average volume of alcohol consumption, type of beverage and drin..
L Baglietto, G Severi, DR English, JL Hopper, GG Giles
2006-09-15
Although there is little evidence to support an association between alcohol consumption and prostate cancer risk, questions remain..
2006-06-01
Aims: To examine associations between amount and frequency of alcohol consumption, and Type 2 diabetes. Methods: A prospective stu..
RJ MacInnis, DR English, JL Hopper, GG Giles
2006-05-15
Although evidence has been mounting that obesity may be related to the increased incidence of oesophageal and gastric cardia malig..
RJ MacInnis, DR English, JL Hopper, DM Gertig, AM Haydon, GG Giles
2006-03-15
Studies of colon cancer risk in males have reported strong positive associations with obesity, particularly with central adiposity..
L Baglietto, MA Jenkins, G Severi, GG Giles, DT Bishop, P Boyle, JL Hopper
2006-02-01
Objective: Familial aggregation, a primary theme in genetic epidemiology, can be estimated from family studies based on an index p..
E Milne, P Jacoby, B Giles-Corti, D Cross, R Johnston, DR English
2006-01-01
Background. Recognition that early sun exposure is an important risk factor for cutaneous melanoma in white populations has led to..
L Baglietto, DR English, DM Gertig, JL Hopper, GG Giles
2005-10-08
Objective: To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk. Des..
2004-11-01
OBJECTIVE - To examine associations between type 2 diabetes and fiber, glycemic load (GL), dietary glycemic index (GI), and fiber-..
2004-10-01
OBJECTIVE - The aims of the study were to determine whether Greek or Italian migrants to Australia have an elevated incidence of t..
AM Hodge, DR English, MRE McCredie, G Severi, P Boyle, JL Hopper, GG Giles
2004-02-01
Objective: To examine the risk of prostate cancer associated with foods and nutrients, including individual fatty acids and carote..